Variable Effects of Nonsteroidal Antiinflammatory Agents on Thyroid Test Results

M. H. Samuels; K. Pillote; D. Asher; J. C. Nelson

doi:10.1210/jc.2002-021869

Variable Effects of Nonsteroidal Antiinflammatory Agents on Thyroid Test Results

M. H. Samuels, K. Pillote, D. Asher, J. C. Nelson

Endocrinology

Research output: Contribution to journal › Article

17 Scopus citations

Abstract

To investigate the effects of nonsteroidal antiinflammatory drugs (NSAIDs) on thyroid tests, 25 healthy subjects underwent a single-dose study and/or a 1-wk study. In the single-dose study, subjects received a single dose of one of six NSAIDs (aspirin, salsalate, meclofenamate, ibuprofen, naproxen, or indomethacin) at 0800 h. Total and free thyroid hormones and TSH were analyzed 0, 1, 2, 3, 4, and 8 h later. In the 1-wk study, subjects received one of six NSAIDs for 7 d. Thyroid hormones and TSH were analyzed at 0800 h each day. Total T₄ and total T₃ were measured by RIA, free T ₄ and free T₃ were measured by equilibrium dialysis, and TSH was measured by immunometric assay. There were no changes in any hormones after a single dose or 1 wk of ibuprofen, naproxen, or indomethacin. Single-dose aspirin or salsalate decreased, whereas meclofenamate increased, various total and free thyroid hormone measurements. One week of aspirin or salsalate decreased total T₄, free T₄ (salsalate only), total T₃, free T₃, and TSH. These data confirm that aspirin, salsalate, and meclofenamate affect total and free thyroid hormone measurements and identify three NSAIDs that did not change thyroid tests. TSH remained within the normal range during acute or 1-wk administration of all of the NSAIDs.

Original language	English (US)
Pages (from-to)	5710-5716
Number of pages	7
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	88
Issue number	12
DOIs	https://doi.org/10.1210/jc.2002-021869
State	Published - Dec 1 2003

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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Samuels, M. H., Pillote, K., Asher, D., & Nelson, J. C. (2003). Variable Effects of Nonsteroidal Antiinflammatory Agents on Thyroid Test Results. Journal of Clinical Endocrinology and Metabolism, 88(12), 5710-5716. https://doi.org/10.1210/jc.2002-021869

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abstract = "To investigate the effects of nonsteroidal antiinflammatory drugs (NSAIDs) on thyroid tests, 25 healthy subjects underwent a single-dose study and/or a 1-wk study. In the single-dose study, subjects received a single dose of one of six NSAIDs (aspirin, salsalate, meclofenamate, ibuprofen, naproxen, or indomethacin) at 0800 h. Total and free thyroid hormones and TSH were analyzed 0, 1, 2, 3, 4, and 8 h later. In the 1-wk study, subjects received one of six NSAIDs for 7 d. Thyroid hormones and TSH were analyzed at 0800 h each day. Total T4 and total T3 were measured by RIA, free T 4 and free T3 were measured by equilibrium dialysis, and TSH was measured by immunometric assay. There were no changes in any hormones after a single dose or 1 wk of ibuprofen, naproxen, or indomethacin. Single-dose aspirin or salsalate decreased, whereas meclofenamate increased, various total and free thyroid hormone measurements. One week of aspirin or salsalate decreased total T4, free T4 (salsalate only), total T3, free T3, and TSH. These data confirm that aspirin, salsalate, and meclofenamate affect total and free thyroid hormone measurements and identify three NSAIDs that did not change thyroid tests. TSH remained within the normal range during acute or 1-wk administration of all of the NSAIDs.",

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