Variability of brain lithium levels during maintenance treatment: A magnetic resonance spectroscopy study

Gary S. Sachs, Perry F. Renshaw, Beny Lafer, Andrew L. Stoll, Alexander Guimaraes, Jerrold F. Rosenbaum, R. Gilberto Gonzalez

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

In vivo magnetic resonance spectroscopy (MRS) was used to determine the relationship between serum and brain lithium levels in bipolar patients (n = 25). Over the broad range of serum lithium levels observed, the correlation (r = .68) with brain lithium levels was high. This correlation was much weaker (r = .39) when limited to only those patients with serum lithium levels in the range of 0.6-1.0 mmol/l. This variability may account for failure of lithium prophylaxis in some patients who have serum lithium levels in the therapeutic range.

Original languageEnglish (US)
Pages (from-to)422-428
Number of pages7
JournalBiological Psychiatry
Volume38
Issue number7
DOIs
StatePublished - Oct 1 1995
Externally publishedYes

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Lithium
Magnetic Resonance Spectroscopy
Brain
Serum
Therapeutics

Keywords

  • bipolar disorder
  • Brain
  • brain imaging
  • lithium
  • magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Variability of brain lithium levels during maintenance treatment : A magnetic resonance spectroscopy study. / Sachs, Gary S.; Renshaw, Perry F.; Lafer, Beny; Stoll, Andrew L.; Guimaraes, Alexander; Rosenbaum, Jerrold F.; Gonzalez, R. Gilberto.

In: Biological Psychiatry, Vol. 38, No. 7, 01.10.1995, p. 422-428.

Research output: Contribution to journalArticle

Sachs, Gary S. ; Renshaw, Perry F. ; Lafer, Beny ; Stoll, Andrew L. ; Guimaraes, Alexander ; Rosenbaum, Jerrold F. ; Gonzalez, R. Gilberto. / Variability of brain lithium levels during maintenance treatment : A magnetic resonance spectroscopy study. In: Biological Psychiatry. 1995 ; Vol. 38, No. 7. pp. 422-428.
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