Vancomycin-resistant Enterococcus in liver transplant patients

Susan Orloff, Ann M H Busch, Ali J. Olyaei, Christopher Corless, Kent G. Benner, Ken D. Flora, Hugo R. Rosen, John M. Rabkin

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Vancomycin-resistant Enterococcus (VRE) infection is emerging in the transplant population, and there is no effective antibiotic therapy available. The aims of this retrospective review were to (1) investigate the outcome of and (2) identify common characteristics associated with VRE infection and colonization in orthotopic liver transplant (OLTx) candidates. METHODS: From October 1994 through September 1998, 126 isolates of VRE were identified in 42 of 234 OLTx recipients and 5 OLTx candidates who did not proceed to transplantation. Data were collected by patient chart review or from a computerized hospital database. RESULTS: The 1-year mortality rate with VRE infection was 82%, and with VRE colonization, 7%. This mortality rate contrasts with a 14% 1-year mortality for non-VRE transplant patients (P 2.5 mg/dL or need for dialysis; 43%). Biliary complications were seen in 52% of postOLTx VRE-infected or VRE-colonized patients (versus 22% in non-VRE transplant patients, P

Original languageEnglish (US)
Pages (from-to)418-422
Number of pages5
JournalAmerican Journal of Surgery
Volume177
Issue number5
DOIs
StatePublished - May 1999

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Transplants
Liver
Enterococcus
Mortality
Infection
Vancomycin-Resistant Enterococci
Dialysis
Transplantation
Databases
Anti-Bacterial Agents
Population
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Orloff, S., Busch, A. M. H., Olyaei, A. J., Corless, C., Benner, K. G., Flora, K. D., ... Rabkin, J. M. (1999). Vancomycin-resistant Enterococcus in liver transplant patients. American Journal of Surgery, 177(5), 418-422. https://doi.org/10.1016/S0002-9610(99)00083-5

Vancomycin-resistant Enterococcus in liver transplant patients. / Orloff, Susan; Busch, Ann M H; Olyaei, Ali J.; Corless, Christopher; Benner, Kent G.; Flora, Ken D.; Rosen, Hugo R.; Rabkin, John M.

In: American Journal of Surgery, Vol. 177, No. 5, 05.1999, p. 418-422.

Research output: Contribution to journalArticle

Orloff, S, Busch, AMH, Olyaei, AJ, Corless, C, Benner, KG, Flora, KD, Rosen, HR & Rabkin, JM 1999, 'Vancomycin-resistant Enterococcus in liver transplant patients', American Journal of Surgery, vol. 177, no. 5, pp. 418-422. https://doi.org/10.1016/S0002-9610(99)00083-5
Orloff, Susan ; Busch, Ann M H ; Olyaei, Ali J. ; Corless, Christopher ; Benner, Kent G. ; Flora, Ken D. ; Rosen, Hugo R. ; Rabkin, John M. / Vancomycin-resistant Enterococcus in liver transplant patients. In: American Journal of Surgery. 1999 ; Vol. 177, No. 5. pp. 418-422.
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