Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4

Moriah Sandy; Andrew Han; John Blunt; Murray Munro; Margo Haygood; Alison Butler

doi:10.1021/np900750g

Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4

Moriah Sandy, Andrew Han, John Blunt, Murray Munro, Margo Haygood, Alison Butler

Research output: Contribution to journal › Article › peer-review

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Abstract

The marine bacterium Vibrio sp. DS40M4 has been found to produce a new triscatechol amide siderophore, trivanchrobactin (1), a related new biscatecholamide compound, divanchrobactin (2), and the previously reported siderophores vanchrobactin (3) and anguibactin (4). Vanchrobactin is comprised of l-serine, d-arginine, and 2,3-dihydroxybenzoic acid, while trivanchrobactin is a linear trimer of vanchrobactin joined by two serine ester linkages. The cyclic trivanchrobactin product was not detected. In addition to siderophore production, extracts of Vibrio sp. DS40M4 were screened for biologically active molecules; anguibactin was found to be cytotoxic against the P388 murine leukemia cell line (IC₅₀ < 15 μM).

Original language	English (US)
Pages (from-to)	1038-1043
Number of pages	6
Journal	Journal of Natural Products
Volume	73
Issue number	6
DOIs	https://doi.org/10.1021/np900750g
State	Published - Jun 25 2010

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4",

abstract = "The marine bacterium Vibrio sp. DS40M4 has been found to produce a new triscatechol amide siderophore, trivanchrobactin (1), a related new biscatecholamide compound, divanchrobactin (2), and the previously reported siderophores vanchrobactin (3) and anguibactin (4). Vanchrobactin is comprised of l-serine, d-arginine, and 2,3-dihydroxybenzoic acid, while trivanchrobactin is a linear trimer of vanchrobactin joined by two serine ester linkages. The cyclic trivanchrobactin product was not detected. In addition to siderophore production, extracts of Vibrio sp. DS40M4 were screened for biologically active molecules; anguibactin was found to be cytotoxic against the P388 murine leukemia cell line (IC50 < 15 μM).",

author = "Moriah Sandy and Andrew Han and John Blunt and Murray Munro and Margo Haygood and Alison Butler",

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T1 - Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4

AU - Sandy, Moriah

AU - Han, Andrew

AU - Blunt, John

AU - Munro, Murray

AU - Haygood, Margo

AU - Butler, Alison

PY - 2010/6/25

Y1 - 2010/6/25

N2 - The marine bacterium Vibrio sp. DS40M4 has been found to produce a new triscatechol amide siderophore, trivanchrobactin (1), a related new biscatecholamide compound, divanchrobactin (2), and the previously reported siderophores vanchrobactin (3) and anguibactin (4). Vanchrobactin is comprised of l-serine, d-arginine, and 2,3-dihydroxybenzoic acid, while trivanchrobactin is a linear trimer of vanchrobactin joined by two serine ester linkages. The cyclic trivanchrobactin product was not detected. In addition to siderophore production, extracts of Vibrio sp. DS40M4 were screened for biologically active molecules; anguibactin was found to be cytotoxic against the P388 murine leukemia cell line (IC50 < 15 μM).

AB - The marine bacterium Vibrio sp. DS40M4 has been found to produce a new triscatechol amide siderophore, trivanchrobactin (1), a related new biscatecholamide compound, divanchrobactin (2), and the previously reported siderophores vanchrobactin (3) and anguibactin (4). Vanchrobactin is comprised of l-serine, d-arginine, and 2,3-dihydroxybenzoic acid, while trivanchrobactin is a linear trimer of vanchrobactin joined by two serine ester linkages. The cyclic trivanchrobactin product was not detected. In addition to siderophore production, extracts of Vibrio sp. DS40M4 were screened for biologically active molecules; anguibactin was found to be cytotoxic against the P388 murine leukemia cell line (IC50 < 15 μM).

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Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4

Abstract

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