Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4

Moriah Sandy, Andrew Han, John Blunt, Murray Munro, Margo Haygood, Alison Butler

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33 Scopus citations

Abstract

The marine bacterium Vibrio sp. DS40M4 has been found to produce a new triscatechol amide siderophore, trivanchrobactin (1), a related new biscatecholamide compound, divanchrobactin (2), and the previously reported siderophores vanchrobactin (3) and anguibactin (4). Vanchrobactin is comprised of l-serine, d-arginine, and 2,3-dihydroxybenzoic acid, while trivanchrobactin is a linear trimer of vanchrobactin joined by two serine ester linkages. The cyclic trivanchrobactin product was not detected. In addition to siderophore production, extracts of Vibrio sp. DS40M4 were screened for biologically active molecules; anguibactin was found to be cytotoxic against the P388 murine leukemia cell line (IC50 < 15 μM).

Original languageEnglish (US)
Pages (from-to)1038-1043
Number of pages6
JournalJournal of Natural Products
Volume73
Issue number6
DOIs
StatePublished - Jun 25 2010

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Sandy, M., Han, A., Blunt, J., Munro, M., Haygood, M., & Butler, A. (2010). Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4. Journal of Natural Products, 73(6), 1038-1043. https://doi.org/10.1021/np900750g