Value of Medical Therapy in Patients >80 Years of Age With Heart Failure and Preserved Ejection Fraction

Faramarz Tehrani, Anita Phan, Christopher V. Chien, Ryan P. Morrissey, Asim M. Rafique, Ernst R. Schwarz

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Heart failure (HF) with preserved ejection fraction (EF) has a high prevalence in the geriatric population, and this cohort may be at risk of complications caused by polypharmacy. Effects of commonly used cardiac medications on long-term survival of patients >80 years with HF and preserved left ventricular EF were assessed. One hundred forty-two patients were evaluated. During a 5-year follow-up, 98 patients died (69%). There were no significant differences in baseline parameters in patients who died compared with those who survived at 5 years. None of the drug therapies appeared to make a significant difference in long-term survival, including β blockers (p = 0.89), angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (p = 0.91), calcium channel blockers (p = 0.69), diuretics (p = 0.30), digoxin (p = 0.22), and statins (p = 0.32). In conclusion, based on the present data, it appears that use of certain common cardiac medications may not be associated with a significant effect on long-term survival in octogenarians with HF and preserved EF.

Original languageEnglish (US)
Pages (from-to)829-833
Number of pages5
JournalAmerican Journal of Cardiology
Issue number6
StatePublished - Mar 15 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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