TY - JOUR
T1 - Value of Medical Therapy in Patients >80 Years of Age With Heart Failure and Preserved Ejection Fraction
AU - Tehrani, Faramarz
AU - Phan, Anita
AU - Chien, Christopher V.
AU - Morrissey, Ryan P.
AU - Rafique, Asim M.
AU - Schwarz, Ernst R.
PY - 2009/3/15
Y1 - 2009/3/15
N2 - Heart failure (HF) with preserved ejection fraction (EF) has a high prevalence in the geriatric population, and this cohort may be at risk of complications caused by polypharmacy. Effects of commonly used cardiac medications on long-term survival of patients >80 years with HF and preserved left ventricular EF were assessed. One hundred forty-two patients were evaluated. During a 5-year follow-up, 98 patients died (69%). There were no significant differences in baseline parameters in patients who died compared with those who survived at 5 years. None of the drug therapies appeared to make a significant difference in long-term survival, including β blockers (p = 0.89), angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (p = 0.91), calcium channel blockers (p = 0.69), diuretics (p = 0.30), digoxin (p = 0.22), and statins (p = 0.32). In conclusion, based on the present data, it appears that use of certain common cardiac medications may not be associated with a significant effect on long-term survival in octogenarians with HF and preserved EF.
AB - Heart failure (HF) with preserved ejection fraction (EF) has a high prevalence in the geriatric population, and this cohort may be at risk of complications caused by polypharmacy. Effects of commonly used cardiac medications on long-term survival of patients >80 years with HF and preserved left ventricular EF were assessed. One hundred forty-two patients were evaluated. During a 5-year follow-up, 98 patients died (69%). There were no significant differences in baseline parameters in patients who died compared with those who survived at 5 years. None of the drug therapies appeared to make a significant difference in long-term survival, including β blockers (p = 0.89), angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (p = 0.91), calcium channel blockers (p = 0.69), diuretics (p = 0.30), digoxin (p = 0.22), and statins (p = 0.32). In conclusion, based on the present data, it appears that use of certain common cardiac medications may not be associated with a significant effect on long-term survival in octogenarians with HF and preserved EF.
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U2 - 10.1016/j.amjcard.2008.11.047
DO - 10.1016/j.amjcard.2008.11.047
M3 - Article
C2 - 19268740
AN - SCOPUS:61749092896
SN - 0002-9149
VL - 103
SP - 829
EP - 833
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 6
ER -