Valproate use in the older manic patient

B. H. McFarland, M. R. Miller, A. A. Straumfjord

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78 Scopus citations


The authors present a case series of seven older (mean age = 66 years) state hospital patients treated with valproate as an adjunct to conventional medications. The patients had had affective disorder (chiefly bipolar disorder) for an average of 31 years. Most had been hospitalized at the state hospital for several years. Previous unsuccessful treatments had included lithium, carbamazepine, antipsychotics, benzodiazepines, and antidepressants and electroconvulsive therapy in one patient. After 1 month of adjunctive treatment, valproate led to marked improvement in three patients, moderate improvement in two, minimal improvement in one, and no change in one patient with delusional depression. Global Assessment Scale scores increased over baseline an average of 29 points (p = .01). Valproate proved to be safe in these older individuals, many of whom had several medical conditions.

Original languageEnglish (US)
Pages (from-to)479-481
Number of pages3
JournalJournal of Clinical Psychiatry
Issue number11
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Psychiatry and Mental health


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