Validation of the SF-6D health state utilities measure in lower extremity sarcoma

Kenneth R. Gundle, Amy M. Cizik, Stephanie E.W. Punt, Ernest U. Conrad, Darin J. Davidson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Aim. Health state utilities measures are preference-weighted patient-reported outcome (PRO) instruments that facilitate comparative effectiveness research. One such measure, the SF-6D, is generated from the Short Form 36 (SF-36). This report describes a psychometric evaluation of the SF-6D in a cross-sectional population of lower extremity sarcoma patients. Methods. Patients with lower extremity sarcoma from a prospective database who had completed the SF-36 and Toronto Extremity Salvage Score (TESS) were eligible for inclusion. Computed SF-6D health states were given preference weights based on a prior valuation. The primary outcome was correlation between the SF-6D and TESS. Results. In 63 pairs of surveys in a lower extremity sarcoma population, the mean preference-weighted SF-6D score was 0.59 (95% CI 0.4-0.81). The distribution of SF-6D scores approximated a normal curve (skewness = 0.11). There was a positive correlation between the SF-6D and TESS (r = 0.75, P < 0.01). Respondents who reported walking aid use had lower SF-6D scores (0.53 versus 0.61, P = 0.03). Five respondents underwent amputation, with lower SF-6D scores that approached significance (0.48 versus 0.6, P = 0.06). Conclusions. The SF-6D health state utilities measure demonstrated convergent validity without evidence of ceiling or floor effects. The SF-6D is a health state utilities measure suitable for further research in sarcoma patients.

Original languageEnglish (US)
Article number450902
JournalSarcoma
Volume2014
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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    Gundle, K. R., Cizik, A. M., Punt, S. E. W., Conrad, E. U., & Davidson, D. J. (2014). Validation of the SF-6D health state utilities measure in lower extremity sarcoma. Sarcoma, 2014, [450902]. https://doi.org/10.1155/2014/450902