Validation of the Myocardial Performance Index by Echocardiography in Mice: A Noninvasive Measure of Left Ventricular Function

Craig Broberg, George Pantely, Brent J. Barber, Gordon K. Mack, Kathryn Lee, Timothy Thigpen, Lowell Davis, David Sahn, Alan (Roger) Hohimer

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Background: The myocardial performance index (MPI) is a Doppler-based measure of left ventricular (LV) function. It is noninvasive, independent of LV shape, and does not require dimensional measurements. However, it has never been validated in mice. Methods: A total of 29 anesthetized mice with IV pressure catheters underwent echocardiography (2-dimensional, M-mode, and Doppler) at baseline and during manipulations of β-adrenergic tone, temperature, preload, and afterload. The maximum derivative of LV pressure with respect to time (dP/dtmax) was compared with MPI, fractional shortening (FS), mean velocity of circumferential fiber shortening, and the FS/MPI ratio. Results: MPI (baseline 0.44 ± 0.07) correlated strongly with dP/dtmax (R = -.779, P × .001), as did FS and mean velocity of circumferential fiber shortening. MPI differed significantly with contractility, preload, and afterload manipulation. FS/MPI showed the best correlation with dP/dtmax. Conclusions: MPI strongly correlates with dP/dtmax over a range of hemodynamic conditions in mice. It can be used as a noninvasive index of LV function in this species.

Original languageEnglish (US)
Pages (from-to)814-823
Number of pages10
JournalJournal of the American Society of Echocardiography
Issue number8
Publication statusPublished - Aug 2003


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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