Validation of the Myocardial Performance Index by Echocardiography in Mice: A Noninvasive Measure of Left Ventricular Function

Craig S. Broberg, George A. Pantely, Brent J. Barber, Gordon K. Mack, Kathryn Lee, Timothy Thigpen, Lowell E. Davis, David Sahn, A. Roger Hohimer

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Background: The myocardial performance index (MPI) is a Doppler-based measure of left ventricular (LV) function. It is noninvasive, independent of LV shape, and does not require dimensional measurements. However, it has never been validated in mice. Methods: A total of 29 anesthetized mice with IV pressure catheters underwent echocardiography (2-dimensional, M-mode, and Doppler) at baseline and during manipulations of β-adrenergic tone, temperature, preload, and afterload. The maximum derivative of LV pressure with respect to time (dP/dtmax) was compared with MPI, fractional shortening (FS), mean velocity of circumferential fiber shortening, and the FS/MPI ratio. Results: MPI (baseline 0.44 ± 0.07) correlated strongly with dP/dtmax (R = -.779, P × .001), as did FS and mean velocity of circumferential fiber shortening. MPI differed significantly with contractility, preload, and afterload manipulation. FS/MPI showed the best correlation with dP/dtmax. Conclusions: MPI strongly correlates with dP/dtmax over a range of hemodynamic conditions in mice. It can be used as a noninvasive index of LV function in this species.

Original languageEnglish (US)
Pages (from-to)814-823
Number of pages10
JournalJournal of the American Society of Echocardiography
Volume16
Issue number8
DOIs
StatePublished - Aug 2003

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Validation of the Myocardial Performance Index by Echocardiography in Mice: A Noninvasive Measure of Left Ventricular Function'. Together they form a unique fingerprint.

  • Cite this