Validation of electronic health record phenotyping of bipolar disorder cases and controls

Victor M. Castro, Jessica Minnier, Shawn N. Murphy, Isaac Kohane, Susanne E. Churchill, Vivian Gainer, Tianxi Cai, Alison G. Hoffnagle, Yael Dai, Stefanie Block, Sydney R. Weill, Mireya Nadal-Vicens, Alisha R. Pollastri, J. Niels Rosenquist, Sergey Goryachev, Dost Ongur, Pamela Sklar, Roy H. Perlis, Jordan W. Smoller, Phil Hyoun LeeEli A. Stahl, Shaun M. Purcell, Douglas M. Ruderfer, Alexander W. Charney, Panos Roussos, Carlos Pato, Michele Pato, Helen Medeiros, Janet Sobel, Nick Craddock, Ian Jones, Liz Forty, Arianna DiFlorio, Elaine Green, Lisa Jones, Katherine Dunjewski, Mikael Landén, Christina Hultman, Anders Juréus, Sarah Bergen, Oscar Svantesson, Steven McCarroll, Jennifer Moran, Kimberly Chambert, Richard A. Belliveau

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Objective: The study was designed to validate use of electronic health records (EHRs) for diagnosing bipolar disorder and classifying control subjects. Method: EHR data were obtained from a health care system of more than 4.6 million patients spanning more than 20 years. Experienced clinicians reviewed charts to identify text features and coded data consistent or inconsistent with a diagnosis of bipolar disorder. Natural language processing was used to train a diagnostic algorithm with 95% specificity for classifying bipolar disorder. Filtered coded data were used to derive three additional classification rules for case subjects and one for control subjects. The positive predictive value (PPV) of EHR-based bipolar disorder and subphenotype diagnoses was calculated against diagnoses from direct semistructured interviews of 190 patients by trained clinicians blind to EHR diagnosis. Results: The PPV of bipolar disorder defined by natural language processing was 0.85. Coded classification based on strict filtering achieved a value of 0.79, but classifications based on less stringent criteria performed less well. No EHRclassified control subject received a diagnosis of bipolar disorder on the basis of direct interview (PPV=1.0). For most subphenotypes, values exceeded 0.80. The EHR-based classifications were used to accrue 4,500 bipolar disorder cases and 5,000 controls for genetic analyses. Conclusions: Semiautomatedmining of EHRs can be used to ascertain bipolar disorder patients and control subjects with high specificity and predictive value compared with diagnostic interviews. EHRs provide a powerful resource for highthroughput phenotyping for genetic and clinical research.

Original languageEnglish (US)
Pages (from-to)363-372
Number of pages10
JournalAmerican Journal of Psychiatry
Volume172
Issue number4
DOIs
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Validation of electronic health record phenotyping of bipolar disorder cases and controls'. Together they form a unique fingerprint.

  • Cite this

    Castro, V. M., Minnier, J., Murphy, S. N., Kohane, I., Churchill, S. E., Gainer, V., Cai, T., Hoffnagle, A. G., Dai, Y., Block, S., Weill, S. R., Nadal-Vicens, M., Pollastri, A. R., Rosenquist, J. N., Goryachev, S., Ongur, D., Sklar, P., Perlis, R. H., Smoller, J. W., ... Belliveau, R. A. (2015). Validation of electronic health record phenotyping of bipolar disorder cases and controls. American Journal of Psychiatry, 172(4), 363-372. https://doi.org/10.1176/appi.ajp.2014.14030423