Vagotomy plus Bilroth II gastrectomy for the prevention of recurrent alcohol-induced pancreatitis

H. H. Stone, R. J. Mullins, W. A. Scovill

    Research output: Contribution to journalArticle

    10 Scopus citations

    Abstract

    Three retrospective reviews documenting a lessened frequency of acute recurrent alcohol-induced pancreatitis following vagotomy, with or without gastrectomy or gastroenterostomy, prompted a prospective evaluation of truncal vagotomy with Bilroth II gastrectomy as a means of preventing such exacerbations. Randomization between operation and encouragement to abstain from alcohol in patients with a history of more than one, but less than ten, acute bouts of alcohol-induced pancreatitis was set by odd-even digits in the hospital number. Of 176 patients admitted with acute alcoholic pancreatitis during 23 months of study, 49 were excluded because of too few or too many prior attacks. Another 61 refused to enter the study. At least one (average 1.9) recurrence requiring hospitalization was noted in 49, or 80%, of these patients on follow-up for 2 to 26 months (average 14 months). Of the 66 who consented to participate, 33 were randomized not to undergo operation and had almost identical recurrence statistics (i.e., an average of 1.7 recurrences in 24, or 73%). By contrast, only two of 31, or six per cent, allocated to operation have experienced a recurrence (p < 0.001). Two who had been randomized were excluded because of persisting active pancreatitis.

    Original languageEnglish (US)
    Pages (from-to)684-689
    Number of pages6
    JournalAnnals of surgery
    Volume201
    Issue number6
    DOIs
    StatePublished - Jan 1 1985

    ASJC Scopus subject areas

    • Surgery

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