Vagal afferent activation decreases brown adipose tissue (BAT) sympathetic nerve activity and BAT thermogenesis

Christopher (Chris) Madden, Ellen Paula Santos da Conceicao, Shaun Morrison

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In urethane/α-chloralose anesthetized rats, electrical stimulation of cervical vagal afferent fibers inhibited the increases in brown adipose tissue sympathetic nerve activity and brown adipose tissue thermogenesis evoked by cold exposure, by nanoinjection of the GABAA receptor antagonist, bicuculline, in the dorsomedial hypothalamus, and by nanoinjection of N-methyl-D-aspartate in the rostral raphe pallidus. Vagus nerve stimulation-evoked inhibition of brown adipose tissue sympathetic nerve activity was prevented by blockade of ionotropic glutamate receptors in the termination site of vagal afferents in the nucleus of the solitary tract, and by nanoinjection of GABAA receptor antagonists in the rostral raphe pallidus. In conclusion, the brown adipose tissue sympathoinhibitory effect of cervical afferent vagal nerve stimulation is mediated by glutamatergic activation of second-order sensory neurons in the nucleus of the solitary tract and by a GABAergic inhibition of brown adipose tissue sympathetic premotor neurons in the rostral raphe pallidus, but does not require GABAergic inhibition of the brown adipose tissue sympathoexcitatory neurons in the dorsomedial hypothalamus.

Original languageEnglish (US)
Pages (from-to)89-96
Number of pages8
JournalTemperature
Volume4
Issue number1
DOIs
StatePublished - Mar 31 2017

Fingerprint

Brown Adipose Tissue
Thermogenesis
Vagus Nerve Stimulation
GABA-A Receptor Antagonists
Solitary Nucleus
Hypothalamus
Ionotropic Glutamate Receptors
Neurons
Chloralose
Bicuculline
Urethane
Sensory Receptor Cells
N-Methylaspartate
Electric Stimulation

Keywords

  • NTS
  • raphe pallidus
  • thermoregulation
  • vagus
  • VNS

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Vagal afferent activation decreases brown adipose tissue (BAT) sympathetic nerve activity and BAT thermogenesis. / Madden, Christopher (Chris); Santos da Conceicao, Ellen Paula; Morrison, Shaun.

In: Temperature, Vol. 4, No. 1, 31.03.2017, p. 89-96.

Research output: Contribution to journalArticle

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