Vaccine-induced linear epitope-specific antibodies to simian immunodeficiency virus SIVmac239 envelope are distinct from those induced to the human immunodeficiency virus type 1 envelope in nonhuman primates

Xiaoying Shen, Ryan Duffy, Robert Howington, Alethea Cope, Shanmugalakshmi Sadagopal, Haesun Park, Ranajit Pal, Suefen Kwa, Song Ding, Otto O. Yang, Genevieve G. Fouda, Roger Le Grand, Diane Bolton, Mariano Esteban, Sanjay Phogat, Mario Roederer, Rama R. Amara, Louis Picker, Robert A. Seder, M. Juliana McElrathSusan Barnett, Sallie R. Permar, Robin Shattock, Anthony L. DeVico, Barbara K. Felber, George N. Pavlakis, Giuseppe Pantaleo, Bette T. Korber, David C. Montefiori, Georgia D. Tomaras

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen.

Original languageEnglish (US)
Pages (from-to)8643-8650
Number of pages8
JournalJournal of Virology
Volume89
Issue number16
DOIs
StatePublished - 2015

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Simian immunodeficiency virus
Simian Immunodeficiency Virus
Human immunodeficiency virus 1
Primates
epitopes
HIV-1
Epitopes
Vaccines
vaccines
antibodies
Antibodies
antigens
Antibody Specificity
Antibody Formation
Immunoglobulin G
Antigens

ASJC Scopus subject areas

  • Immunology
  • Virology

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Vaccine-induced linear epitope-specific antibodies to simian immunodeficiency virus SIVmac239 envelope are distinct from those induced to the human immunodeficiency virus type 1 envelope in nonhuman primates. / Shen, Xiaoying; Duffy, Ryan; Howington, Robert; Cope, Alethea; Sadagopal, Shanmugalakshmi; Park, Haesun; Pal, Ranajit; Kwa, Suefen; Ding, Song; Yang, Otto O.; Fouda, Genevieve G.; Grand, Roger Le; Bolton, Diane; Esteban, Mariano; Phogat, Sanjay; Roederer, Mario; Amara, Rama R.; Picker, Louis; Seder, Robert A.; Juliana McElrath, M.; Barnett, Susan; Permar, Sallie R.; Shattock, Robin; DeVico, Anthony L.; Felber, Barbara K.; Pavlakis, George N.; Pantaleo, Giuseppe; Korber, Bette T.; Montefiori, David C.; Tomaras, Georgia D.

In: Journal of Virology, Vol. 89, No. 16, 2015, p. 8643-8650.

Research output: Contribution to journalArticle

Shen, X, Duffy, R, Howington, R, Cope, A, Sadagopal, S, Park, H, Pal, R, Kwa, S, Ding, S, Yang, OO, Fouda, GG, Grand, RL, Bolton, D, Esteban, M, Phogat, S, Roederer, M, Amara, RR, Picker, L, Seder, RA, Juliana McElrath, M, Barnett, S, Permar, SR, Shattock, R, DeVico, AL, Felber, BK, Pavlakis, GN, Pantaleo, G, Korber, BT, Montefiori, DC & Tomaras, GD 2015, 'Vaccine-induced linear epitope-specific antibodies to simian immunodeficiency virus SIVmac239 envelope are distinct from those induced to the human immunodeficiency virus type 1 envelope in nonhuman primates', Journal of Virology, vol. 89, no. 16, pp. 8643-8650. https://doi.org/10.1128/JVI.03635-14
Shen, Xiaoying ; Duffy, Ryan ; Howington, Robert ; Cope, Alethea ; Sadagopal, Shanmugalakshmi ; Park, Haesun ; Pal, Ranajit ; Kwa, Suefen ; Ding, Song ; Yang, Otto O. ; Fouda, Genevieve G. ; Grand, Roger Le ; Bolton, Diane ; Esteban, Mariano ; Phogat, Sanjay ; Roederer, Mario ; Amara, Rama R. ; Picker, Louis ; Seder, Robert A. ; Juliana McElrath, M. ; Barnett, Susan ; Permar, Sallie R. ; Shattock, Robin ; DeVico, Anthony L. ; Felber, Barbara K. ; Pavlakis, George N. ; Pantaleo, Giuseppe ; Korber, Bette T. ; Montefiori, David C. ; Tomaras, Georgia D. / Vaccine-induced linear epitope-specific antibodies to simian immunodeficiency virus SIVmac239 envelope are distinct from those induced to the human immunodeficiency virus type 1 envelope in nonhuman primates. In: Journal of Virology. 2015 ; Vol. 89, No. 16. pp. 8643-8650.
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AU - Howington, Robert

AU - Cope, Alethea

AU - Sadagopal, Shanmugalakshmi

AU - Park, Haesun

AU - Pal, Ranajit

AU - Kwa, Suefen

AU - Ding, Song

AU - Yang, Otto O.

AU - Fouda, Genevieve G.

AU - Grand, Roger Le

AU - Bolton, Diane

AU - Esteban, Mariano

AU - Phogat, Sanjay

AU - Roederer, Mario

AU - Amara, Rama R.

AU - Picker, Louis

AU - Seder, Robert A.

AU - Juliana McElrath, M.

AU - Barnett, Susan

AU - Permar, Sallie R.

AU - Shattock, Robin

AU - DeVico, Anthony L.

AU - Felber, Barbara K.

AU - Pavlakis, George N.

AU - Pantaleo, Giuseppe

AU - Korber, Bette T.

AU - Montefiori, David C.

AU - Tomaras, Georgia D.

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