Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice

Halina Offner, Kirsten Adlard, Bruce F. Bebo, Jeanette Schuster, Gregory G. Burrows, Abigail C. Buenafe, Arthur A. Vandenbark

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

TCR determinants overexpressed by autopathogenic Th1 cells can naturally induce a second set of TCR-specific regulatory T cells. We addressed the question of whether immune regulation could be induced naturally in a genetically restricted model in which a major portion of TCR-specific regulatory T cells expressed the same target TCR BV8S2 chain as the pathogenic T cells specific for myelin basic protein (MBP). We found vigorous T cell responses to BV8S2 determinants in naive mice that could be further potentiated by vaccination with heterologous BV8S2 proteins, resulting in the selective inhibition of MBP-specific Th1 cells and protection against experimental encephalomyelitis. Moreover, coculture with BV8S2-specific T cells or their supernatants reduced proliferation, IFN-γ/secretion, and encephalitogenic activity of MBP-specific T cells. These results suggest that immune regulation occurs through a nondeletional cytokine-driven suppressive mechanism.

Original languageEnglish (US)
Pages (from-to)2178-2186
Number of pages9
JournalJournal of Immunology
Volume161
Issue number5
StatePublished - Sep 1 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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