Vβ CDR3 motifs associated with BP recognition are enriched in OX-40+ spinal cord T cells of Lewis rats with EAE

A. C. Buenafe, A. D. Weinberg, N. E. Culbertson, A. A. Vandenbark, H. Offner

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Spinal cord (SC) T cells were isolated at the onset of actively induced experimental autoimmune encephalomyelitis (EAE) and sorted for the presence of the OX-40 activation marker. Previously, we reported an enhanced bias in Vβ8.2 expression as well as enhanced proliferative responses to basic protein antigens among the OX-40+ SC T cells. Here we demonstrate that CDR3 motifs associated with EAE are present at a significantly higher frequency in Vβ8.2 sequences of OX-40+ SC T cells (16/17) compared with those of OX- 40- SC T cells (5/17). Thus, the OX-40 antigen may be useful as a marker to isolate and characterize autoantigen-specific T cells from the site of inflammation in T-cell-mediated autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)562-567
Number of pages6
JournalJournal of Neuroscience Research
Volume44
Issue number6
DOIs
StatePublished - Jun 15 1996

    Fingerprint

Keywords

  • MS
  • TCR Vβ
  • autoimmunity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this