Vβ CDR3 motifs associated with BP recognition are enriched in OX-40+ spinal cord T cells of Lewis rats with EAE

A. C. Buenafe, A. D. Weinberg, N. E. Culbertson, Arthur Vandenbark, Halina Offner

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Spinal cord (SC) T cells were isolated at the onset of actively induced experimental autoimmune encephalomyelitis (EAE) and sorted for the presence of the OX-40 activation marker. Previously, we reported an enhanced bias in Vβ8.2 expression as well as enhanced proliferative responses to basic protein antigens among the OX-40+ SC T cells. Here we demonstrate that CDR3 motifs associated with EAE are present at a significantly higher frequency in Vβ8.2 sequences of OX-40+ SC T cells (16/17) compared with those of OX- 40- SC T cells (5/17). Thus, the OX-40 antigen may be useful as a marker to isolate and characterize autoantigen-specific T cells from the site of inflammation in T-cell-mediated autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)562-567
Number of pages6
JournalJournal of Neuroscience Research
Volume44
Issue number6
DOIs
StatePublished - Jun 15 1996

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Autoimmune Experimental Encephalomyelitis
Spinal Cord
T-Lymphocytes
Antigens
Autoantigens
Autoimmune Diseases
Inflammation
Proteins

Keywords

  • autoimmunity
  • MS
  • TCR Vβ

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vβ CDR3 motifs associated with BP recognition are enriched in OX-40+ spinal cord T cells of Lewis rats with EAE. / Buenafe, A. C.; Weinberg, A. D.; Culbertson, N. E.; Vandenbark, Arthur; Offner, Halina.

In: Journal of Neuroscience Research, Vol. 44, No. 6, 15.06.1996, p. 562-567.

Research output: Contribution to journalArticle

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AU - Vandenbark, Arthur

AU - Offner, Halina

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