Uveitis secondary to bacterial products

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Bacteria are suspected contributors to several forms of immune-mediated, noninfectious forms of uveitis including that associated with ankylosing spondylitis, sarcoidosis, Behçet's disease and inflammatory bowel disease. Endotoxin (lipopolysaccharide)-induced uveitis has been a widely used model for more than 2 decades. Both rats and mice develop a transient, bilateral anterior uveitis after a systemic injection of endotoxin. Inflammation posterior to the lens is generally milder than anterior segment inflammation. The uveitis is severer if the lipopolysaccharides are injected intraocularly. The model has been invaluable in helping to identify mediators induced in the inflamed eye and in testing pharmacologic approaches to reduce eye inflammation. Muramyl dipeptide is another bacterial cell component that can induce uveitis in laboratory animals. Muramyl dipeptide is especially intriguing as a cause of uveitis because it activates the intracellular protein, Nod2, and mutations in the NOD2 gene are the cause of the autosomal dominant form of uveitis that is characteristic of Blau syndrome. Since a mutation in a gene that codes for a protein which senses a bacterial product consistently results in uveitis, it is critical to understand more fully the mechanisms by which bacterial products cause uveitis in laboratory animals.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalOphthalmic Research
Volume40
Issue number3-4
DOIs
StatePublished - Apr 2008

Fingerprint

Uveitis
Acetylmuramyl-Alanyl-Isoglutamine
Laboratory Animals
Inflammation
Endotoxins
Lipopolysaccharides
Anterior Uveitis
Mutation
Ankylosing Spondylitis
Cellular Structures
Sarcoidosis
Inflammatory Bowel Diseases
Lenses
Genes
Proteins
Bacteria
Injections

Keywords

  • Endotoxin
  • Muramyl dipeptide
  • NOD2
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Uveitis secondary to bacterial products. / Rosenbaum, James (Jim); Rosenzweig, Holly; Smith, Justine R.; Martin, Tammy; Planck, Stephen.

In: Ophthalmic Research, Vol. 40, No. 3-4, 04.2008, p. 165-168.

Research output: Contribution to journalArticle

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