Uveal melanomas presenting during pregnancy and the investigation of oestrogen receptors in melanomas

J. M. Seddon, D. T. MacLaughlin, Daniel Albert, E. S. Gragoudas, M. Ference

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

We observed a young woman who showed growth of a choroidal melanoma over the course of 2 pregnancies, with subsequent enucleation of the eye. This is the first such documented case. In addition 4 other women with uveal malignant melanomas presented during pregnancy. This observed number of pregnancies (5) was greater than the expected number (2.1) among women of childbearing age who underwent enucleation with subsequent analysis in our pathology laboratory. However, this difference was not statistically significant. Further, more females 44 years of age of younger underwent enucleation for malignant melanoma than men of comparable age. Evaluation of these cases led us to propose that there is a subset of patients whose ocular melanomas are hormonally responsive. We therefore analysed uveal melanoma and choroidal tissue from 7 patients, including one of the pregnant women, for the presence of oestrogen receptors. No specific oestrogen binding was found. The possibilities that other hormones are involved or an immunological mechanism is operative are discussed.

Original languageEnglish (US)
Pages (from-to)695-704
Number of pages10
JournalUnknown Journal
Volume66
Issue number11
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

Fingerprint

Estrogen Receptors
Melanoma
Pregnancy
Eye Enucleation
Pregnant Women
Estrogens
Hormones
Pathology
Uveal melanoma
Growth

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Uveal melanomas presenting during pregnancy and the investigation of oestrogen receptors in melanomas. / Seddon, J. M.; MacLaughlin, D. T.; Albert, Daniel; Gragoudas, E. S.; Ference, M.

In: Unknown Journal, Vol. 66, No. 11, 01.01.1982, p. 695-704.

Research output: Contribution to journalArticle

Seddon, J. M. ; MacLaughlin, D. T. ; Albert, Daniel ; Gragoudas, E. S. ; Ference, M. / Uveal melanomas presenting during pregnancy and the investigation of oestrogen receptors in melanomas. In: Unknown Journal. 1982 ; Vol. 66, No. 11. pp. 695-704.
@article{8d6b60c1193e4746ab1116b4dcdbf592,
title = "Uveal melanomas presenting during pregnancy and the investigation of oestrogen receptors in melanomas",
abstract = "We observed a young woman who showed growth of a choroidal melanoma over the course of 2 pregnancies, with subsequent enucleation of the eye. This is the first such documented case. In addition 4 other women with uveal malignant melanomas presented during pregnancy. This observed number of pregnancies (5) was greater than the expected number (2.1) among women of childbearing age who underwent enucleation with subsequent analysis in our pathology laboratory. However, this difference was not statistically significant. Further, more females 44 years of age of younger underwent enucleation for malignant melanoma than men of comparable age. Evaluation of these cases led us to propose that there is a subset of patients whose ocular melanomas are hormonally responsive. We therefore analysed uveal melanoma and choroidal tissue from 7 patients, including one of the pregnant women, for the presence of oestrogen receptors. No specific oestrogen binding was found. The possibilities that other hormones are involved or an immunological mechanism is operative are discussed.",
author = "Seddon, {J. M.} and MacLaughlin, {D. T.} and Daniel Albert and Gragoudas, {E. S.} and M. Ference",
year = "1982",
month = "1",
day = "1",
doi = "10.1136/bjo.66.11.695",
language = "English (US)",
volume = "66",
pages = "695--704",
journal = "Indian Journal of Rheumatology",
issn = "0973-3698",
publisher = "Elsevier (Singapore) Pte Ltd",
number = "11",

}

TY - JOUR

T1 - Uveal melanomas presenting during pregnancy and the investigation of oestrogen receptors in melanomas

AU - Seddon, J. M.

AU - MacLaughlin, D. T.

AU - Albert, Daniel

AU - Gragoudas, E. S.

AU - Ference, M.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - We observed a young woman who showed growth of a choroidal melanoma over the course of 2 pregnancies, with subsequent enucleation of the eye. This is the first such documented case. In addition 4 other women with uveal malignant melanomas presented during pregnancy. This observed number of pregnancies (5) was greater than the expected number (2.1) among women of childbearing age who underwent enucleation with subsequent analysis in our pathology laboratory. However, this difference was not statistically significant. Further, more females 44 years of age of younger underwent enucleation for malignant melanoma than men of comparable age. Evaluation of these cases led us to propose that there is a subset of patients whose ocular melanomas are hormonally responsive. We therefore analysed uveal melanoma and choroidal tissue from 7 patients, including one of the pregnant women, for the presence of oestrogen receptors. No specific oestrogen binding was found. The possibilities that other hormones are involved or an immunological mechanism is operative are discussed.

AB - We observed a young woman who showed growth of a choroidal melanoma over the course of 2 pregnancies, with subsequent enucleation of the eye. This is the first such documented case. In addition 4 other women with uveal malignant melanomas presented during pregnancy. This observed number of pregnancies (5) was greater than the expected number (2.1) among women of childbearing age who underwent enucleation with subsequent analysis in our pathology laboratory. However, this difference was not statistically significant. Further, more females 44 years of age of younger underwent enucleation for malignant melanoma than men of comparable age. Evaluation of these cases led us to propose that there is a subset of patients whose ocular melanomas are hormonally responsive. We therefore analysed uveal melanoma and choroidal tissue from 7 patients, including one of the pregnant women, for the presence of oestrogen receptors. No specific oestrogen binding was found. The possibilities that other hormones are involved or an immunological mechanism is operative are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0020378817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020378817&partnerID=8YFLogxK

U2 - 10.1136/bjo.66.11.695

DO - 10.1136/bjo.66.11.695

M3 - Article

C2 - 7126514

AN - SCOPUS:0020378817

VL - 66

SP - 695

EP - 704

JO - Indian Journal of Rheumatology

JF - Indian Journal of Rheumatology

SN - 0973-3698

IS - 11

ER -