Uveal Malignant Melanoma Associated with Ocular and Oculodermal Melanocytosis

John R. Gonder, Jerry A. Shields, Daniel Albert, James J. Augsburger, Philip T. Lavin

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Seventeen patients with ocular or oculodermal melanocytosis were identified among 1,250 Caucasian patients with uveal malignant melanoma. The uveal melanomas in these seventeen patients were similar in size, cell type, and tendency to metastasize to those occurring in reported populations without ocular or oculodermal melanocytosis. Clinical and histopathologic study of these 17 cases indicated that all of the affected eyes had episcleral and choroidal melanocytosis and that other ocular and periocular tissues (sclera, iris, conjunctiva, angle structures, and optic disc) were involved less commonly. The uveal malignant melanoma that was present in each of these cases involved the eye with melanocytosis. Furthermore, the melanoma arose from the zone of uveal melanocytosis in every eye with sectoral involvement. Statistical analysis of these data supports the contention that uveal malignant melanoma has a higher incidence in white persons with ocular or oculodermal melanocytosis than in those without these conditions.

Original languageEnglish (US)
Pages (from-to)953-960
Number of pages8
JournalOphthalmology
Volume89
Issue number8
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

Fingerprint

Melanoma
Statistical Data Interpretation
Sclera
Conjunctiva
Optic Disk
Iris
Uveal melanoma
Cell Size
Incidence
Population

Keywords

  • ocular melanocytosis
  • oculodermal melanocytosis
  • uveal malignant melanoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Uveal Malignant Melanoma Associated with Ocular and Oculodermal Melanocytosis. / Gonder, John R.; Shields, Jerry A.; Albert, Daniel; Augsburger, James J.; Lavin, Philip T.

In: Ophthalmology, Vol. 89, No. 8, 01.01.1982, p. 953-960.

Research output: Contribution to journalArticle

Gonder, John R. ; Shields, Jerry A. ; Albert, Daniel ; Augsburger, James J. ; Lavin, Philip T. / Uveal Malignant Melanoma Associated with Ocular and Oculodermal Melanocytosis. In: Ophthalmology. 1982 ; Vol. 89, No. 8. pp. 953-960.
@article{1b6a64616c664b58acf612a78b0871a9,
title = "Uveal Malignant Melanoma Associated with Ocular and Oculodermal Melanocytosis",
abstract = "Seventeen patients with ocular or oculodermal melanocytosis were identified among 1,250 Caucasian patients with uveal malignant melanoma. The uveal melanomas in these seventeen patients were similar in size, cell type, and tendency to metastasize to those occurring in reported populations without ocular or oculodermal melanocytosis. Clinical and histopathologic study of these 17 cases indicated that all of the affected eyes had episcleral and choroidal melanocytosis and that other ocular and periocular tissues (sclera, iris, conjunctiva, angle structures, and optic disc) were involved less commonly. The uveal malignant melanoma that was present in each of these cases involved the eye with melanocytosis. Furthermore, the melanoma arose from the zone of uveal melanocytosis in every eye with sectoral involvement. Statistical analysis of these data supports the contention that uveal malignant melanoma has a higher incidence in white persons with ocular or oculodermal melanocytosis than in those without these conditions.",
keywords = "ocular melanocytosis, oculodermal melanocytosis, uveal malignant melanoma",
author = "Gonder, {John R.} and Shields, {Jerry A.} and Daniel Albert and Augsburger, {James J.} and Lavin, {Philip T.}",
year = "1982",
month = "1",
day = "1",
doi = "10.1016/S0161-6420(82)34694-1",
language = "English (US)",
volume = "89",
pages = "953--960",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Uveal Malignant Melanoma Associated with Ocular and Oculodermal Melanocytosis

AU - Gonder, John R.

AU - Shields, Jerry A.

AU - Albert, Daniel

AU - Augsburger, James J.

AU - Lavin, Philip T.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Seventeen patients with ocular or oculodermal melanocytosis were identified among 1,250 Caucasian patients with uveal malignant melanoma. The uveal melanomas in these seventeen patients were similar in size, cell type, and tendency to metastasize to those occurring in reported populations without ocular or oculodermal melanocytosis. Clinical and histopathologic study of these 17 cases indicated that all of the affected eyes had episcleral and choroidal melanocytosis and that other ocular and periocular tissues (sclera, iris, conjunctiva, angle structures, and optic disc) were involved less commonly. The uveal malignant melanoma that was present in each of these cases involved the eye with melanocytosis. Furthermore, the melanoma arose from the zone of uveal melanocytosis in every eye with sectoral involvement. Statistical analysis of these data supports the contention that uveal malignant melanoma has a higher incidence in white persons with ocular or oculodermal melanocytosis than in those without these conditions.

AB - Seventeen patients with ocular or oculodermal melanocytosis were identified among 1,250 Caucasian patients with uveal malignant melanoma. The uveal melanomas in these seventeen patients were similar in size, cell type, and tendency to metastasize to those occurring in reported populations without ocular or oculodermal melanocytosis. Clinical and histopathologic study of these 17 cases indicated that all of the affected eyes had episcleral and choroidal melanocytosis and that other ocular and periocular tissues (sclera, iris, conjunctiva, angle structures, and optic disc) were involved less commonly. The uveal malignant melanoma that was present in each of these cases involved the eye with melanocytosis. Furthermore, the melanoma arose from the zone of uveal melanocytosis in every eye with sectoral involvement. Statistical analysis of these data supports the contention that uveal malignant melanoma has a higher incidence in white persons with ocular or oculodermal melanocytosis than in those without these conditions.

KW - ocular melanocytosis

KW - oculodermal melanocytosis

KW - uveal malignant melanoma

UR - http://www.scopus.com/inward/record.url?scp=0019988381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019988381&partnerID=8YFLogxK

U2 - 10.1016/S0161-6420(82)34694-1

DO - 10.1016/S0161-6420(82)34694-1

M3 - Article

VL - 89

SP - 953

EP - 960

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 8

ER -