Utilizing mouse models of human cancer for assessing immune modulation of cancer development

Karin E. de Visser; Lisa M. Coussens

doi:10.1007/978-0-387-69805-2_21

Utilizing mouse models of human cancer for assessing immune modulation of cancer development

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The availability and diversity of mouse models of human cancer that develop organ-specific neoplasms has increased significantly in the past 10 years. These, coupled with mouse strains where components of the immune system have been manipulated or deleted, have provided novel insights into how immune cells and immune function significantly contributes to cancer development. Herein, we review relevant literature, where mouse models of human cancer development have provided novel insights into mechanisms of pro- versus antitumor immunity.

Original language	English (US)
Title of host publication	Genetically Engineered Mice for Cancer Research
Subtitle of host publication	Design, Analysis, Pathways, Validation and Pre-Clinical Testing
Publisher	Springer New York
Pages	443-463
Number of pages	21
ISBN (Electronic)	9780387698052
ISBN (Print)	9780387698038
DOIs	https://doi.org/10.1007/978-0-387-69805-2_21
State	Published - Jan 1 2012
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1007/978-0-387-69805-2_21

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abstract = "The availability and diversity of mouse models of human cancer that develop organ-specific neoplasms has increased significantly in the past 10 years. These, coupled with mouse strains where components of the immune system have been manipulated or deleted, have provided novel insights into how immune cells and immune function significantly contributes to cancer development. Herein, we review relevant literature, where mouse models of human cancer development have provided novel insights into mechanisms of pro- versus antitumor immunity.",

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Utilizing mouse models of human cancer for assessing immune modulation of cancer development

Abstract

ASJC Scopus subject areas

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