Utilizing mouse models of human cancer for assessing immune modulation of cancer development

Karin E. de Visser, Lisa M. Coussens

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The availability and diversity of mouse models of human cancer that develop organ-specific neoplasms has increased significantly in the past 10 years. These, coupled with mouse strains where components of the immune system have been manipulated or deleted, have provided novel insights into how immune cells and immune function significantly contributes to cancer development. Herein, we review relevant literature, where mouse models of human cancer development have provided novel insights into mechanisms of pro- versus antitumor immunity.

Original languageEnglish (US)
Title of host publicationGenetically Engineered Mice for Cancer Research
Subtitle of host publicationDesign, Analysis, Pathways, Validation and Pre-Clinical Testing
PublisherSpringer New York
Pages443-463
Number of pages21
ISBN (Electronic)9780387698052
ISBN (Print)9780387698038
DOIs
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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