Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs

Bita Moghaddam, Benjamin S. Bunney

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Moghaddam, Bita and Benjamin S. Bunney: Utilization of Microdialysls for Assessing the Release of Mesotelencephallc Dopamlne Following Clozapine and Other Antlpsychotic Drugs. Prog. Neuro-PsychopharmacoI. & Biol. Psychiat. 1990, 14 (Suppl): S51-S57. 1. 1. In vivo microdialysis was utilized to assess the effect of clozapine, haloperidol and sulpiride on the release of dopamine from the nucleus accumbens, striatum and prefrontal cortex of the rat. 2. 2. The results suggest that acute administration of various classes of antipsychotic drugs may differentially increase the extracellular concentration of dopamine in mesotelencephalic systems. Haloperidol and sulpiride were more effective in releasing dopamine from the terminals of the nigrostriatal dopamine system while clozapine had a more prefrontal effect on the mesolimbic and particularly the mesocortical dopamine systems.

Original languageEnglish (US)
Pages (from-to)S51-S57
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume14
Issue numberSUPPL. 1
DOIs
StatePublished - 1990

Keywords

  • clozapine
  • dopamine
  • microdialysis
  • prefrontal cortex

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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