Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs

Bita Moghaddam; Benjamin S. Bunney

doi:10.1016/0278-5846(90)90086-V

Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs

Bita Moghaddam, Benjamin S. Bunney

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Moghaddam, Bita and Benjamin S. Bunney: Utilization of Microdialysls for Assessing the Release of Mesotelencephallc Dopamlne Following Clozapine and Other Antlpsychotic Drugs. Prog. Neuro-PsychopharmacoI. & Biol. Psychiat. 1990, 14 (Suppl): S51-S57. 1. 1. In vivo microdialysis was utilized to assess the effect of clozapine, haloperidol and sulpiride on the release of dopamine from the nucleus accumbens, striatum and prefrontal cortex of the rat. 2. 2. The results suggest that acute administration of various classes of antipsychotic drugs may differentially increase the extracellular concentration of dopamine in mesotelencephalic systems. Haloperidol and sulpiride were more effective in releasing dopamine from the terminals of the nigrostriatal dopamine system while clozapine had a more prefrontal effect on the mesolimbic and particularly the mesocortical dopamine systems.

Original language	English (US)
Pages (from-to)	S51-S57
Journal	Progress in Neuropsychopharmacology and Biological Psychiatry
Volume	14
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/0278-5846(90)90086-V
State	Published - 1990
Externally published	Yes

Keywords

clozapine
dopamine
microdialysis
prefrontal cortex

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/0278-5846(90)90086-V

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title = "Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs",

abstract = "Moghaddam, Bita and Benjamin S. Bunney: Utilization of Microdialysls for Assessing the Release of Mesotelencephallc Dopamlne Following Clozapine and Other Antlpsychotic Drugs. Prog. Neuro-PsychopharmacoI. & Biol. Psychiat. 1990, 14 (Suppl): S51-S57. 1. 1. In vivo microdialysis was utilized to assess the effect of clozapine, haloperidol and sulpiride on the release of dopamine from the nucleus accumbens, striatum and prefrontal cortex of the rat. 2. 2. The results suggest that acute administration of various classes of antipsychotic drugs may differentially increase the extracellular concentration of dopamine in mesotelencephalic systems. Haloperidol and sulpiride were more effective in releasing dopamine from the terminals of the nigrostriatal dopamine system while clozapine had a more prefrontal effect on the mesolimbic and particularly the mesocortical dopamine systems.",

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AU - Moghaddam, Bita

AU - Bunney, Benjamin S.

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Y1 - 1990

N2 - Moghaddam, Bita and Benjamin S. Bunney: Utilization of Microdialysls for Assessing the Release of Mesotelencephallc Dopamlne Following Clozapine and Other Antlpsychotic Drugs. Prog. Neuro-PsychopharmacoI. & Biol. Psychiat. 1990, 14 (Suppl): S51-S57. 1. 1. In vivo microdialysis was utilized to assess the effect of clozapine, haloperidol and sulpiride on the release of dopamine from the nucleus accumbens, striatum and prefrontal cortex of the rat. 2. 2. The results suggest that acute administration of various classes of antipsychotic drugs may differentially increase the extracellular concentration of dopamine in mesotelencephalic systems. Haloperidol and sulpiride were more effective in releasing dopamine from the terminals of the nigrostriatal dopamine system while clozapine had a more prefrontal effect on the mesolimbic and particularly the mesocortical dopamine systems.

AB - Moghaddam, Bita and Benjamin S. Bunney: Utilization of Microdialysls for Assessing the Release of Mesotelencephallc Dopamlne Following Clozapine and Other Antlpsychotic Drugs. Prog. Neuro-PsychopharmacoI. & Biol. Psychiat. 1990, 14 (Suppl): S51-S57. 1. 1. In vivo microdialysis was utilized to assess the effect of clozapine, haloperidol and sulpiride on the release of dopamine from the nucleus accumbens, striatum and prefrontal cortex of the rat. 2. 2. The results suggest that acute administration of various classes of antipsychotic drugs may differentially increase the extracellular concentration of dopamine in mesotelencephalic systems. Haloperidol and sulpiride were more effective in releasing dopamine from the terminals of the nigrostriatal dopamine system while clozapine had a more prefrontal effect on the mesolimbic and particularly the mesocortical dopamine systems.

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KW - dopamine

KW - microdialysis

KW - prefrontal cortex

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Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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