Using metabotropic glutamate receptors to modulate cocaine's synaptic and behavioral effects: MGluR1 finds a niche

Jessica A. Loweth, Kuei Y. Tseng, Marina E. Wolf

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Group I metabotropic glutamate receptors (mGluR) are important modulators of excitatory synaptic transmission and therefore potential targets for drug development. In several brain regions (ventral tegmental area (VTA), cerebellum, and amygdala), stimulation of mGluR1 selectively inhibits synaptic transmission mediated by calcium-permeable AMPA receptors (CP-AMPARs) and thus produces synaptic depression. The same relationship has now been demonstrated in the nucleus accumbens (NAc), a region that is critical for cocaine craving. CP-AMPAR levels in NAc synapses are normally low, but they increase after prolonged withdrawal from extended-access cocaine self-administration (SA). These CP-AMPARs mediate the intensified ('incubated') cue-induced cocaine craving observed under these conditions. Therefore, activation of mGluR1 with positive allosteric modulators (PAM) may reduce cue-induced relapse in abstinent cocaine addicts.

Original languageEnglish (US)
Pages (from-to)500-506
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume23
Issue number4
DOIs
StatePublished - Aug 2013
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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