Using Healthcare Data in Embedded Pragmatic Clinical Trials among People Living with Dementia and Their Caregivers: State of the Art

Julie P.W. Bynum, David A. Dorr, Julie Lima, Ellen P. McCarthy, Ellen McCreedy, Richard Platt, V. G.Vinod Vydiswaran

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Embedded pragmatic clinical trials (ePCTs) are embedded in healthcare systems as well as their data environments. For people living with dementia (PLWD), settings of care can be different from the general population and involve additional people whose information is also important. The ePCT designs have the opportunity to leverage data that becomes available through the normal delivery of care. They may be particularly valuable in Alzheimer's disease and Alzheimer's disease-related dementia (AD/ADRD), given the complexity of case identification and the diversity of care settings. Grounded in the objectives of the Data and Technical Core of the newly established National Institute on Aging Imbedded Pragmatic Alzheimer's Disease and AD-Related Dementias Clinical Trials Collaboratory (IMPACT Collaboratory), this article summarizes the state of the art in using existing data sources (eg, Medicare claims, electronic health records) in AD/ADRD ePCTs and approaches to integrating them in real-world settings. J Am Geriatr Soc 68:S49–S54, 2020.

Original languageEnglish (US)
Pages (from-to)S49-S54
JournalJournal of the American Geriatrics Society
Volume68
Issue numberS2
DOIs
StatePublished - Jul 1 2020

Keywords

  • Alzheimer's disease
  • dementia
  • measurement
  • pragmatic trial

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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