@article{1dfa20739b4a49359224f24c8fd1bf6e,
title = "Using Healthcare Data in Embedded Pragmatic Clinical Trials among People Living with Dementia and Their Caregivers: State of the Art",
abstract = "Embedded pragmatic clinical trials (ePCTs) are embedded in healthcare systems as well as their data environments. For people living with dementia (PLWD), settings of care can be different from the general population and involve additional people whose information is also important. The ePCT designs have the opportunity to leverage data that becomes available through the normal delivery of care. They may be particularly valuable in Alzheimer's disease and Alzheimer's disease-related dementia (AD/ADRD), given the complexity of case identification and the diversity of care settings. Grounded in the objectives of the Data and Technical Core of the newly established National Institute on Aging Imbedded Pragmatic Alzheimer's Disease and AD-Related Dementias Clinical Trials Collaboratory (IMPACT Collaboratory), this article summarizes the state of the art in using existing data sources (eg, Medicare claims, electronic health records) in AD/ADRD ePCTs and approaches to integrating them in real-world settings. J Am Geriatr Soc 68:S49–S54, 2020.",
keywords = "Alzheimer's disease, dementia, measurement, pragmatic trial",
author = "Bynum, {Julie P.W.} and Dorr, {David A.} and Julie Lima and McCarthy, {Ellen P.} and Ellen McCreedy and Richard Platt and Vydiswaran, {V. G.Vinod}",
note = "Funding Information: This work was supported by the National Institute on Aging (NIA) of the National Institutes of Health under Award Number U54AG063546 that funds the NIA Imbedded Pragmatic Alzheimer's Disease and AD-Related Dementias Clinical Trials Collaboratory (NIA IMPACT Collaboratory). All authors are members of the Technical Data Core, and none have declared any conflicts of interest for this article. All authors are members of the Technical Data Core and contributed to all phases of writing this manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: This work was supported by the National Institute on Aging (NIA) of the National Institutes of Health under Award Number U54AG063546 that funds the NIA Imbedded Pragmatic Alzheimer's Disease and AD‐Related Dementias Clinical Trials Collaboratory (NIA IMPACT Collaboratory). Publisher Copyright: {\textcopyright} 2020 The American Geriatrics Society",
year = "2020",
month = jul,
day = "1",
doi = "10.1111/jgs.16617",
language = "English (US)",
volume = "68",
pages = "S49--S54",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "S2",
}