Using Digital Tools to Advance Alzheimer’s Drug Trials During a Pandemic: The EU/US CTAD Task Force

the EU/US CTAD Task Force

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The 2020 COVID-19 pandemic has disrupted Alzheimer’s disease (AD) clinical studies worldwide. Digital technologies may help minimize disruptions by enabling remote assessment of subtle cognitive and functional changes over the course of the disease. The EU/US Clinical Trials in Alzheimer’s Disease (CTAD) Task Force met virtually in November 2020 to explore the opportunities and challenges associated with the use of digital technologies in AD clinical research. While recognizing the potential of digital tools to accelerate clinical trials, improve the engagement of diverse populations, capture clinically meaningful data, and lower costs, questions remain regarding the stability, validity, generalizability, and reproducibility of digital data. Substantial concerns also exist regarding regulatory acceptance and privacy. Nonetheless, the Task Force supported further exploration of digital technologies through collaboration and data sharing, noting the need for standardization of digital readouts. They also concluded that while it may be premature to employ remote assessments for trials of novel experimental medications, remote studies of non-invasive, multi-domain approaches may be feasible at this time.

Original languageEnglish (US)
Pages (from-to)513-519
Number of pages7
JournalThe journal of prevention of Alzheimer's disease
Volume8
Issue number4
DOIs
StatePublished - Sep 2021

Keywords

  • Alzheimer’s disease
  • clinical outcomes
  • digital tools
  • remote assessments

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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