Usefulness of different biochemical markers of the insulin-like growth factor (IGF) family in diagnosing growth hormone excess and deficiency in adults

Paolo Marzullo, Carolina Di Somma, Katherine L. Pratt, Javad Khosravi, Anastasia Diamandis, Gaetano Lombardi, Annamaria Colao, Ronald (Ron) Rosenfeld

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Abstract

The diagnostic approach to acromegaly and GH deficiency frequently includes measurement of several components of the insulin-like growth factor (IGF) system. IGF-I levels are reported to be good predictors of active and cured acromegaly, but are commonly found within the normal age-adjusted range in adult GH-deficient (GHD) patients. Circulating concentrations of IGF-binding protein-3 (IGFBP-3), acid-labile subunit (ALS), and free IGF-I reflect the GH secretory status, but their diagnostic accuracy is still debated. In this study serum levels of total and free IGF-I, IGFBP-3, ALS, and IGFBP-3-IGF-I and IGFBP-3-ALS complexes were determined in patients previously diagnosed with active (n = 67) or inactive (n = 16) acromegaly and adult GHD (n = 34) and compared with results obtained in 58 healthy controls. In healthy subjects, IGF-I, IGFBP-3, ALS, and both IGFBP-3 complexes declined with age; a correlation was found between IGF-I and IGFBP-3 (r = 0.59; P <0.001), ALS (r = 0.67; P <0.001), and free IGF-I (r = 0.40; P <0.05). Active acromegalic patients showed a significant increase in all parameters tested. IGF-I concentrations were above +2 SD in 100% of patients, whereas slightly lower sensitivities were shown for IGFBP-3 (85%), ALS (88%), and free IGF-I (94%). In this group, I GF-I exhibited a slightly higher correlation with IGFBP-3 (r = 0.83; P

Original languageEnglish (US)
Pages (from-to)3001-3008
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume86
Issue number7
DOIs
StatePublished - 2001

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Insulin-Like Growth Factor Binding Protein 3
Somatomedins
Insulin-Like Growth Factor I
Growth Hormone
Biomarkers
Acromegaly
Acids
Growth hormone excess
Healthy Volunteers

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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Usefulness of different biochemical markers of the insulin-like growth factor (IGF) family in diagnosing growth hormone excess and deficiency in adults. / Marzullo, Paolo; Di Somma, Carolina; Pratt, Katherine L.; Khosravi, Javad; Diamandis, Anastasia; Lombardi, Gaetano; Colao, Annamaria; Rosenfeld, Ronald (Ron).

In: Journal of Clinical Endocrinology and Metabolism, Vol. 86, No. 7, 2001, p. 3001-3008.

Research output: Contribution to journalArticle

Marzullo, Paolo ; Di Somma, Carolina ; Pratt, Katherine L. ; Khosravi, Javad ; Diamandis, Anastasia ; Lombardi, Gaetano ; Colao, Annamaria ; Rosenfeld, Ronald (Ron). / Usefulness of different biochemical markers of the insulin-like growth factor (IGF) family in diagnosing growth hormone excess and deficiency in adults. In: Journal of Clinical Endocrinology and Metabolism. 2001 ; Vol. 86, No. 7. pp. 3001-3008.
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abstract = "The diagnostic approach to acromegaly and GH deficiency frequently includes measurement of several components of the insulin-like growth factor (IGF) system. IGF-I levels are reported to be good predictors of active and cured acromegaly, but are commonly found within the normal age-adjusted range in adult GH-deficient (GHD) patients. Circulating concentrations of IGF-binding protein-3 (IGFBP-3), acid-labile subunit (ALS), and free IGF-I reflect the GH secretory status, but their diagnostic accuracy is still debated. In this study serum levels of total and free IGF-I, IGFBP-3, ALS, and IGFBP-3-IGF-I and IGFBP-3-ALS complexes were determined in patients previously diagnosed with active (n = 67) or inactive (n = 16) acromegaly and adult GHD (n = 34) and compared with results obtained in 58 healthy controls. In healthy subjects, IGF-I, IGFBP-3, ALS, and both IGFBP-3 complexes declined with age; a correlation was found between IGF-I and IGFBP-3 (r = 0.59; P <0.001), ALS (r = 0.67; P <0.001), and free IGF-I (r = 0.40; P <0.05). Active acromegalic patients showed a significant increase in all parameters tested. IGF-I concentrations were above +2 SD in 100{\%} of patients, whereas slightly lower sensitivities were shown for IGFBP-3 (85{\%}), ALS (88{\%}), and free IGF-I (94{\%}). In this group, I GF-I exhibited a slightly higher correlation with IGFBP-3 (r = 0.83; P",
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AU - Pratt, Katherine L.

AU - Khosravi, Javad

AU - Diamandis, Anastasia

AU - Lombardi, Gaetano

AU - Colao, Annamaria

AU - Rosenfeld, Ronald (Ron)

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