Use of the saline infusion test to diagnose the cause of primary aldosteronism

Eugenio Arteaga, Robert Klein, Edward G. Biglieri

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Angiotensin II has a major effect on mineralocorticoid hormone synthesis in patients with idiopathic hyperaldosteronism; it has little or no effect in those with an aldosterone-producing adenoma. To determine if this difference could be of use in clinically separating these two forms of primary aldosteronism, saline infusion tests were performed in 20 patients-14 with surgically proved aldosterone-producing adenoma and six with Idiopathic hyperaldosteronism. With the patients receiving a balanced diet containing 120 meq of sodium, 1,250 ml of isotonic saline was infused intravenously between 8 a.m. and 10 a.m. after overnight recumbency. Plasma samples were obtained immediately before and after the infusion. Plasma cortisol level decreased appropriately in both groups, but plasma renin concentration decreased only in those patients with idiopathic hyperaldosteronism (p

Original languageEnglish (US)
Pages (from-to)722-728
Number of pages7
JournalThe American journal of medicine
Volume79
Issue number6
DOIs
StatePublished - 1985
Externally publishedYes

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Hyperaldosteronism
Aldosterone
Adenoma
Mineralocorticoids
Renin
Angiotensin II
Hydrocortisone
Sodium
Hormones
Diet

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Use of the saline infusion test to diagnose the cause of primary aldosteronism. / Arteaga, Eugenio; Klein, Robert; Biglieri, Edward G.

In: The American journal of medicine, Vol. 79, No. 6, 1985, p. 722-728.

Research output: Contribution to journalArticle

Arteaga, Eugenio ; Klein, Robert ; Biglieri, Edward G. / Use of the saline infusion test to diagnose the cause of primary aldosteronism. In: The American journal of medicine. 1985 ; Vol. 79, No. 6. pp. 722-728.
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