Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy

Erika L. Finanger, Barry Russman, Sean C. Forbes, William D. Rooney, Glenn A. Walter, Krista Vandenborne

Research output: Contribution to journalReview article

55 Scopus citations

Abstract

Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. However, these studies have mainly been performed using a cross-sectional design, and the correlation of these MRI changes with disease progression and disease severity has not been fully elucidated. Overall, skeletal muscle MRI is a powerful and sensitive technique in the evaluation of muscle disease, and its use as a biomarker for disease progression or therapeutic response in clinical trials deserves further study.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalPhysical Medicine and Rehabilitation Clinics of North America
Volume23
Issue number1
DOIs
StatePublished - Feb 1 2012

Keywords

  • Duchenne muscular dystrophy
  • MRI
  • Skeletal muscle

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

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