Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology

Grazyna Gora-Maslak, Gerald E. McClearn, John Jr Crabbe, Tamara Phillips, John Belknap, Robert Plomin

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Unlike simple Mendelian characteristics, individual differences in complex quantitative phenotypes studied in psychopharmacology are generally distributed continuously and are likely to be influenced by many genes. Recombinant inbred (RI) strains are valuable not only for their traditional use of detecting major gene segregation and linkage but also for identifying associations between quantitative traits and quantitative trait loci (QTL) that account for relatively small amounts of variation in phenotypes as well as loci that account for greater amounts of variation. When applied to published data on genetic markers and on amphetamine, alcohol, and morphine responses in BXD RI strains (RI strains developed from the cross between C57BL/6J and DBA/2J progenitor inbred strains), the RI QTL approach identified several significant associations beyond known major gene effects. Together, significant associations explain more than half of the genetic variance for these measures. The RI QTL approach is especially valuable for investigating the QTL underpinnings of genetic correlations among measures. It is recommended that psychopharmacogenetic research focus on the BXD RI strains. The cumulative and integrative nature of such a program of research is the major benefit of the RI QTL association approach for molecular genetic analysis of psychopharmacological processes, their physiological infrastructure, and their interface with other behavioral and biological systems.

Original languageEnglish (US)
Pages (from-to)413-424
Number of pages12
JournalPsychopharmacology
Volume104
Issue number4
DOIs
StatePublished - Aug 1991

Fingerprint

Psychopharmacology
Quantitative Trait Loci
Physiological Phenomena
Genes
Phenotype
Amphetamine
Genetic Markers
Research
Individuality
Morphine
Molecular Biology
Alcohols

Keywords

  • Alcohol
  • Amphetamine
  • Association
  • BXD
  • Morphine
  • Quantitative trait loci
  • Quantitative traits
  • Recombinant inbred strains

ASJC Scopus subject areas

  • Pharmacology

Cite this

Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology. / Gora-Maslak, Grazyna; McClearn, Gerald E.; Crabbe, John Jr; Phillips, Tamara; Belknap, John; Plomin, Robert.

In: Psychopharmacology, Vol. 104, No. 4, 08.1991, p. 413-424.

Research output: Contribution to journalArticle

Gora-Maslak, Grazyna ; McClearn, Gerald E. ; Crabbe, John Jr ; Phillips, Tamara ; Belknap, John ; Plomin, Robert. / Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology. In: Psychopharmacology. 1991 ; Vol. 104, No. 4. pp. 413-424.
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