Use of Recombinant Inbred Strains to assess vulnerability to drug abuse at the genetic level

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The use of Recombinant Inbred mouse Strains (RIS) to derive information about the complexity of the genetic architecture underlying various traits is increasing in popularity. Behaviors measured to index sensitivity to drug effects and vulnerability to drug abuse are considered here. Potential uses of RIS are identification of major gene effects, mapping of traits to particular chromosomal sites, determining genetic correlations between characters, and identifying behaviorally extreme genotypes. This approach has led to identification of a major gene moderating alcohol acceptance in mice and has revealed a more complex polygenic system influencing morphine consumption.

Original languageEnglish (US)
Title of host publicationBehavioral and Biochemical Issues in Substance Abuse
PublisherTaylor and Francis
Pages73-87
Number of pages15
ISBN (Electronic)9781315825403
ISBN (Print)9781560240884
DOIs
StatePublished - Jun 3 2014

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ASJC Scopus subject areas

  • Medicine(all)
  • Psychology(all)
  • Social Sciences(all)

Cite this

Phillips, T., Belknap, J., & Crabbe, J. J. (2014). Use of Recombinant Inbred Strains to assess vulnerability to drug abuse at the genetic level. In Behavioral and Biochemical Issues in Substance Abuse (pp. 73-87). Taylor and Francis. https://doi.org/10.4324/9781315825403