Use of Recombinant Inbred Strains to assess vulnerability to drug abuse at the genetic level

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The use of Recombinant Inbred mouse Strains (RIS) to derive information about the complexity of the genetic architecture underlying various traits is increasing in popularity. Behaviors measured to index sensitivity to drug effects and vulnerability to drug abuse are considered here. Potential uses of RIS are identification of major gene effects, mapping of traits to particular chromosomal sites, determining genetic correlations between characters, and identifying behaviorally extreme genotypes. This approach has led to identification of a major gene moderating alcohol acceptance in mice and has revealed a more complex polygenic system influencing morphine consumption.

Original languageEnglish (US)
Title of host publicationBehavioral and Biochemical Issues in Substance Abuse
PublisherTaylor and Francis
Pages73-87
Number of pages15
ISBN (Electronic)9781315825403
ISBN (Print)9781560240884
DOIs
StatePublished - Jun 3 2014

Fingerprint

Inbred Strains Mice
drug abuse
Substance-Related Disorders
vulnerability
Chromosome Mapping
Morphine
popularity
acceptance
alcohol
Genotype
Alcohols
drug
Pharmaceutical Preparations
Genes

ASJC Scopus subject areas

  • Medicine(all)
  • Psychology(all)
  • Social Sciences(all)

Cite this

Phillips, T., Belknap, J., & Crabbe, J. J. (2014). Use of Recombinant Inbred Strains to assess vulnerability to drug abuse at the genetic level. In Behavioral and Biochemical Issues in Substance Abuse (pp. 73-87). Taylor and Francis. https://doi.org/10.4324/9781315825403

Use of Recombinant Inbred Strains to assess vulnerability to drug abuse at the genetic level. / Phillips, Tamara; Belknap, John; Crabbe, John Jr.

Behavioral and Biochemical Issues in Substance Abuse. Taylor and Francis, 2014. p. 73-87.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phillips, T, Belknap, J & Crabbe, JJ 2014, Use of Recombinant Inbred Strains to assess vulnerability to drug abuse at the genetic level. in Behavioral and Biochemical Issues in Substance Abuse. Taylor and Francis, pp. 73-87. https://doi.org/10.4324/9781315825403
Phillips T, Belknap J, Crabbe JJ. Use of Recombinant Inbred Strains to assess vulnerability to drug abuse at the genetic level. In Behavioral and Biochemical Issues in Substance Abuse. Taylor and Francis. 2014. p. 73-87 https://doi.org/10.4324/9781315825403
Phillips, Tamara ; Belknap, John ; Crabbe, John Jr. / Use of Recombinant Inbred Strains to assess vulnerability to drug abuse at the genetic level. Behavioral and Biochemical Issues in Substance Abuse. Taylor and Francis, 2014. pp. 73-87
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