Use of physiologically-based pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity

Mathematics

• Fentanyl 100%
• Opioids 87%
• Analgesics 81%
• Obesity 74%
• Pharmacokinetics 59%
• Children 52%
• Modeling 31%
• Dose 8%
• Physiology 4%
• Prediction Model 4%
• Public Health 4%
• Simulation Model 4%
• Genotype 4%
• Drugs 3%
• Likely 3%
• Fold 3%
• Target 3%
• Knowledge 2%
• Model 2%
• Simulation 2%
• Range of data 2%

Medicine & Life Sciences

• Methadone 55%
• Fentanyl 52%
• Pediatric Obesity 52%
• Opioid Analgesics 42%
• Pharmacokinetics 36%
• Obesity 29%
• Pharmacogenetics 15%
• Cytochrome P-450 CYP2B6 10%
• Child 9%
• Genotype 4%
• Public Health 4%
• Pharmaceutical Preparations 2%

Engineering & Materials Science

• Pharmacokinetics 68%
• Pharmacogenetics 41%
• Cytochrome P-450 Enzyme System 22%
• Physiology 14%
• Public health 14%