Use of genetically distinct mouse populations to explore ethanol reinforcement.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Alcohol-induced locomotor stimulation in mice may provide an animal model of human euphoric responses to moderate alcohol (ethanol) doses. If a common mechanism mediates sensitivity to both drug reward (reinforcement) and drug stimulation, rodent models of drug stimulation would provide powerful tools for investigating drug reinforcement. In addition, stimulant sensitivity might provide a simple marker for susceptibility to ethanol reward, and perhaps addiction (e.g., Newlin and Thomson, 1991). This short report describes the use of three genetic mouse models, (1) FAST and SLOW selectively bred lines, (2) BXD Recombinant Inbred Strains, and (3) a panel of inbred strains of diverse genetic origin, to explore mechanisms mediating ethanol stimulation and reinforcement.

Original languageEnglish (US)
Pages (from-to)451-455
Number of pages5
JournalAlcohol and alcoholism (Oxford, Oxfordshire). Supplement
Volume2
StatePublished - 1993
Externally publishedYes

Fingerprint

Ethanol
Reward
Pharmaceutical Preparations
Population
Alcohols
Genetic Models
Rodentia
Animal Models
Reinforcement (Psychology)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{58298629451449d49bed07abcf21dfbf,
title = "Use of genetically distinct mouse populations to explore ethanol reinforcement.",
abstract = "Alcohol-induced locomotor stimulation in mice may provide an animal model of human euphoric responses to moderate alcohol (ethanol) doses. If a common mechanism mediates sensitivity to both drug reward (reinforcement) and drug stimulation, rodent models of drug stimulation would provide powerful tools for investigating drug reinforcement. In addition, stimulant sensitivity might provide a simple marker for susceptibility to ethanol reward, and perhaps addiction (e.g., Newlin and Thomson, 1991). This short report describes the use of three genetic mouse models, (1) FAST and SLOW selectively bred lines, (2) BXD Recombinant Inbred Strains, and (3) a panel of inbred strains of diverse genetic origin, to explore mechanisms mediating ethanol stimulation and reinforcement.",
author = "Tamara Phillips",
year = "1993",
language = "English (US)",
volume = "2",
pages = "451--455",
journal = "Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.",
issn = "1358-6173",
publisher = "Oxford University Press",

}

TY - JOUR

T1 - Use of genetically distinct mouse populations to explore ethanol reinforcement.

AU - Phillips, Tamara

PY - 1993

Y1 - 1993

N2 - Alcohol-induced locomotor stimulation in mice may provide an animal model of human euphoric responses to moderate alcohol (ethanol) doses. If a common mechanism mediates sensitivity to both drug reward (reinforcement) and drug stimulation, rodent models of drug stimulation would provide powerful tools for investigating drug reinforcement. In addition, stimulant sensitivity might provide a simple marker for susceptibility to ethanol reward, and perhaps addiction (e.g., Newlin and Thomson, 1991). This short report describes the use of three genetic mouse models, (1) FAST and SLOW selectively bred lines, (2) BXD Recombinant Inbred Strains, and (3) a panel of inbred strains of diverse genetic origin, to explore mechanisms mediating ethanol stimulation and reinforcement.

AB - Alcohol-induced locomotor stimulation in mice may provide an animal model of human euphoric responses to moderate alcohol (ethanol) doses. If a common mechanism mediates sensitivity to both drug reward (reinforcement) and drug stimulation, rodent models of drug stimulation would provide powerful tools for investigating drug reinforcement. In addition, stimulant sensitivity might provide a simple marker for susceptibility to ethanol reward, and perhaps addiction (e.g., Newlin and Thomson, 1991). This short report describes the use of three genetic mouse models, (1) FAST and SLOW selectively bred lines, (2) BXD Recombinant Inbred Strains, and (3) a panel of inbred strains of diverse genetic origin, to explore mechanisms mediating ethanol stimulation and reinforcement.

UR - http://www.scopus.com/inward/record.url?scp=0027901653&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027901653&partnerID=8YFLogxK

M3 - Article

C2 - 7748338

AN - SCOPUS:0027901653

VL - 2

SP - 451

EP - 455

JO - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.

JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.

SN - 1358-6173

ER -