Use of functional MRI to guide decisions in a clinical stroke trial.

Steven C. Cramer, Randall R. Benson, David M. Himes, Vijaya C. Burra, Jeri S. Janowsky, Martin E. Weinand, Jeffrey A. Brown, Helmi Lutsep

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: An investigational trial examined safety and efficacy of targeted subthreshold cortical stimulation in patients with chronic stroke. The anatomical location for the target, hand motor area, varies across subjects, and so was localized with functional MRI (fMRI). This report describes the experience of incorporating standardized fMRI into a multisite stroke trial. METHODS: At 3 enrollment centers, patients moved (0.25 Hz) the affected hand during fMRI. Hand motor function was localized at a fourth center guiding intervention for those randomized to stimulation. RESULTS: The fMRI results were available within 24 hours. Across 12 patients, activation site variability was substantial (12, 23, and 11 mm in x, y, and z directions), exceeding stimulating electrode dimensions. CONCLUSIONS: Use of fMRI to guide decision-making in a clinical stroke trial is feasible.

Original languageEnglish (US)
JournalStroke
Volume36
Issue number5
StatePublished - 2005
Externally publishedYes

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Stroke
Magnetic Resonance Imaging
Clinical Trials
Hand
Patient Participation
Motor Cortex
Decision Making
Electrodes
Safety

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Cramer, S. C., Benson, R. R., Himes, D. M., Burra, V. C., Janowsky, J. S., Weinand, M. E., ... Lutsep, H. (2005). Use of functional MRI to guide decisions in a clinical stroke trial. Stroke, 36(5).

Use of functional MRI to guide decisions in a clinical stroke trial. / Cramer, Steven C.; Benson, Randall R.; Himes, David M.; Burra, Vijaya C.; Janowsky, Jeri S.; Weinand, Martin E.; Brown, Jeffrey A.; Lutsep, Helmi.

In: Stroke, Vol. 36, No. 5, 2005.

Research output: Contribution to journalArticle

Cramer, SC, Benson, RR, Himes, DM, Burra, VC, Janowsky, JS, Weinand, ME, Brown, JA & Lutsep, H 2005, 'Use of functional MRI to guide decisions in a clinical stroke trial.', Stroke, vol. 36, no. 5.
Cramer SC, Benson RR, Himes DM, Burra VC, Janowsky JS, Weinand ME et al. Use of functional MRI to guide decisions in a clinical stroke trial. Stroke. 2005;36(5).
Cramer, Steven C. ; Benson, Randall R. ; Himes, David M. ; Burra, Vijaya C. ; Janowsky, Jeri S. ; Weinand, Martin E. ; Brown, Jeffrey A. ; Lutsep, Helmi. / Use of functional MRI to guide decisions in a clinical stroke trial. In: Stroke. 2005 ; Vol. 36, No. 5.
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