TY - JOUR
T1 - Use of diuretics is associated with reduced risk of Alzheimer's disease
T2 - The Cache County study
AU - Cache County Investigators
AU - Chuang, Yi Fang
AU - Breitner, John C.S.
AU - Chiu, Yen Ling
AU - Khachaturian, Ara
AU - Hayden, Kathleen
AU - Corcoran, Chris
AU - Tschanz, Jo Ann
AU - Norton, Maria
AU - Munger, Ron
AU - Welsh-Bohmer, Kathleen
AU - Zandi, Peter P.
AU - Anthony, James
AU - Bigler, Erin
AU - Brookmeyer, Ron
AU - Burke, James
AU - Christopher, Eric
AU - Gagliardi, Jane
AU - Green, Robert
AU - Helms, Michael
AU - Hulette, Christine
AU - Klein, Liz
AU - Leslie, Carol
AU - Lyketsos, Constantine
AU - Morris, John
AU - Onyike, Chiadi
AU - Ostbye, Truls
AU - Petersen, Ron
AU - Piercy, Kathy
AU - Pieper, Carl
AU - Plassman, Brenda
AU - Rabins, Peter
AU - Raj, Pritham
AU - Skoog, Ingmar
AU - Steffens, David
AU - Steinberg, Martin
AU - Toohill, Marty
AU - Toone, Leslie
AU - Townsend, Jeannette
AU - Williams, Michael
AU - Wyse, Bonita
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer's disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal cohort study of dementing illnesses among the elderly population of Cache County, Utah. Using waves I to IV data of the Cache County Study, 3417 participants had a mean of 7.1years of follow-up. Time-varying use of antihypertensive medications including different class of diuretics, angiotensin converting enzyme inhibitors, β-blockers, and calcium channel blockers was used to predict the incidence of AD using Cox proportional hazards analyses. During follow-up, 325 AD cases were ascertained with a total of 23,590 person-years. Use of any antihypertensive medication was associated with lower incidence of AD (adjusted hazard ratio [aHR], 0.77; 95% confidence interval [CI], 0.61-0.97). Among different classes of antihypertensive medications, thiazide (aHR, 0.7; 95% CI, 0.53-0.93), and potassium-sparing diuretics (aHR, 0.69; 95% CI, 0.48-0.99) were associated with the greatest reduction of AD risk. Thiazide and potassium-sparing diuretics were associated with decreased risk of AD. The inverse association of potassium-sparing diuretics confirms an earlier finding in this cohort, now with longer follow-up, and merits further investigation.
AB - Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer's disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal cohort study of dementing illnesses among the elderly population of Cache County, Utah. Using waves I to IV data of the Cache County Study, 3417 participants had a mean of 7.1years of follow-up. Time-varying use of antihypertensive medications including different class of diuretics, angiotensin converting enzyme inhibitors, β-blockers, and calcium channel blockers was used to predict the incidence of AD using Cox proportional hazards analyses. During follow-up, 325 AD cases were ascertained with a total of 23,590 person-years. Use of any antihypertensive medication was associated with lower incidence of AD (adjusted hazard ratio [aHR], 0.77; 95% confidence interval [CI], 0.61-0.97). Among different classes of antihypertensive medications, thiazide (aHR, 0.7; 95% CI, 0.53-0.93), and potassium-sparing diuretics (aHR, 0.69; 95% CI, 0.48-0.99) were associated with the greatest reduction of AD risk. Thiazide and potassium-sparing diuretics were associated with decreased risk of AD. The inverse association of potassium-sparing diuretics confirms an earlier finding in this cohort, now with longer follow-up, and merits further investigation.
KW - Alzheimer's disease
KW - Antihypertensive medications
KW - Diuretics
UR - http://www.scopus.com/inward/record.url?scp=84907214193&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907214193&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2014.05.002
DO - 10.1016/j.neurobiolaging.2014.05.002
M3 - Article
C2 - 24910391
AN - SCOPUS:84907214193
SN - 0197-4580
VL - 35
SP - 2429
EP - 2435
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 11
ER -