Use of concentrated human albumin with argon-beam coagulation in laparoscopic partial nephrectomy

Hua Xie, Jeff S. Teach, Yashodhan S. Khajanchee, Maria C. Anderson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Laparoscopic partial nephrectomy (LPN) remains a technically challenging procedure mainly because of the lack of reliable methods of hemostasis. We evaluated the feasibility of using concentrated human albumin with argon-beam coagulation to control hemorrhaging and urinary leakage during LPN. Materials and Methods: Six domestic swine underwent heparinization, then lower-pole LPN after renal-hilar vascular control had been obtained. The animals received argon-beam coagulation either alone (control) or with 38% albumin. Three days later, an identical procedure was performed on the contralateral kidney. Retrograde pyelography was employed to assess for urine leakage. The animals were then euthanized, and both kidneys were harvested for histologic examination. Results: The mean operative and warm-ischemia times were similar in the two groups and were 27 and 15 minutes, respectively, using albumin with argon-beam coagulation and 25 and 16 minutes with argon coagulation alone. The albumin group required shorter coagulation times (187 v 312 seconds; P = 0.04), which resulted in less thermal injury. By retrograde pyelography, two kidneys (33%) in the albumin group and all six in the control group had urine leakage. Conclusions: Adding concentrated albumin to argon-beam coagulation substantially increases the reliability and durability of parenchymal repair after LPN. The time needed to achieve stable hemostasis and closure of the collecting system was reduced compared with standard argon-beam coagulation.

Original languageEnglish (US)
Pages (from-to)1117-1121
Number of pages5
JournalJournal of Endourology
Volume21
Issue number9
DOIs
StatePublished - Sep 1 2007

Fingerprint

Argon Plasma Coagulation
Nephrectomy
Albumins
Kidney
Urography
Hemostasis
Urine
Warm Ischemia
Argon
Blood Vessels
Swine
Hot Temperature
Control Groups
Wounds and Injuries

ASJC Scopus subject areas

  • Urology

Cite this

Use of concentrated human albumin with argon-beam coagulation in laparoscopic partial nephrectomy. / Xie, Hua; Teach, Jeff S.; Khajanchee, Yashodhan S.; Anderson, Maria C.

In: Journal of Endourology, Vol. 21, No. 9, 01.09.2007, p. 1117-1121.

Research output: Contribution to journalArticle

Xie, Hua ; Teach, Jeff S. ; Khajanchee, Yashodhan S. ; Anderson, Maria C. / Use of concentrated human albumin with argon-beam coagulation in laparoscopic partial nephrectomy. In: Journal of Endourology. 2007 ; Vol. 21, No. 9. pp. 1117-1121.
@article{3889055557224755a510a3c2a49ed448,
title = "Use of concentrated human albumin with argon-beam coagulation in laparoscopic partial nephrectomy",
abstract = "Purpose: Laparoscopic partial nephrectomy (LPN) remains a technically challenging procedure mainly because of the lack of reliable methods of hemostasis. We evaluated the feasibility of using concentrated human albumin with argon-beam coagulation to control hemorrhaging and urinary leakage during LPN. Materials and Methods: Six domestic swine underwent heparinization, then lower-pole LPN after renal-hilar vascular control had been obtained. The animals received argon-beam coagulation either alone (control) or with 38{\%} albumin. Three days later, an identical procedure was performed on the contralateral kidney. Retrograde pyelography was employed to assess for urine leakage. The animals were then euthanized, and both kidneys were harvested for histologic examination. Results: The mean operative and warm-ischemia times were similar in the two groups and were 27 and 15 minutes, respectively, using albumin with argon-beam coagulation and 25 and 16 minutes with argon coagulation alone. The albumin group required shorter coagulation times (187 v 312 seconds; P = 0.04), which resulted in less thermal injury. By retrograde pyelography, two kidneys (33{\%}) in the albumin group and all six in the control group had urine leakage. Conclusions: Adding concentrated albumin to argon-beam coagulation substantially increases the reliability and durability of parenchymal repair after LPN. The time needed to achieve stable hemostasis and closure of the collecting system was reduced compared with standard argon-beam coagulation.",
author = "Hua Xie and Teach, {Jeff S.} and Khajanchee, {Yashodhan S.} and Anderson, {Maria C.}",
year = "2007",
month = "9",
day = "1",
doi = "10.1089/end.2006.0428",
language = "English (US)",
volume = "21",
pages = "1117--1121",
journal = "Journal of Endourology",
issn = "0892-7790",
publisher = "Mary Ann Liebert Inc.",
number = "9",

}

TY - JOUR

T1 - Use of concentrated human albumin with argon-beam coagulation in laparoscopic partial nephrectomy

AU - Xie, Hua

AU - Teach, Jeff S.

AU - Khajanchee, Yashodhan S.

AU - Anderson, Maria C.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Purpose: Laparoscopic partial nephrectomy (LPN) remains a technically challenging procedure mainly because of the lack of reliable methods of hemostasis. We evaluated the feasibility of using concentrated human albumin with argon-beam coagulation to control hemorrhaging and urinary leakage during LPN. Materials and Methods: Six domestic swine underwent heparinization, then lower-pole LPN after renal-hilar vascular control had been obtained. The animals received argon-beam coagulation either alone (control) or with 38% albumin. Three days later, an identical procedure was performed on the contralateral kidney. Retrograde pyelography was employed to assess for urine leakage. The animals were then euthanized, and both kidneys were harvested for histologic examination. Results: The mean operative and warm-ischemia times were similar in the two groups and were 27 and 15 minutes, respectively, using albumin with argon-beam coagulation and 25 and 16 minutes with argon coagulation alone. The albumin group required shorter coagulation times (187 v 312 seconds; P = 0.04), which resulted in less thermal injury. By retrograde pyelography, two kidneys (33%) in the albumin group and all six in the control group had urine leakage. Conclusions: Adding concentrated albumin to argon-beam coagulation substantially increases the reliability and durability of parenchymal repair after LPN. The time needed to achieve stable hemostasis and closure of the collecting system was reduced compared with standard argon-beam coagulation.

AB - Purpose: Laparoscopic partial nephrectomy (LPN) remains a technically challenging procedure mainly because of the lack of reliable methods of hemostasis. We evaluated the feasibility of using concentrated human albumin with argon-beam coagulation to control hemorrhaging and urinary leakage during LPN. Materials and Methods: Six domestic swine underwent heparinization, then lower-pole LPN after renal-hilar vascular control had been obtained. The animals received argon-beam coagulation either alone (control) or with 38% albumin. Three days later, an identical procedure was performed on the contralateral kidney. Retrograde pyelography was employed to assess for urine leakage. The animals were then euthanized, and both kidneys were harvested for histologic examination. Results: The mean operative and warm-ischemia times were similar in the two groups and were 27 and 15 minutes, respectively, using albumin with argon-beam coagulation and 25 and 16 minutes with argon coagulation alone. The albumin group required shorter coagulation times (187 v 312 seconds; P = 0.04), which resulted in less thermal injury. By retrograde pyelography, two kidneys (33%) in the albumin group and all six in the control group had urine leakage. Conclusions: Adding concentrated albumin to argon-beam coagulation substantially increases the reliability and durability of parenchymal repair after LPN. The time needed to achieve stable hemostasis and closure of the collecting system was reduced compared with standard argon-beam coagulation.

UR - http://www.scopus.com/inward/record.url?scp=35349001754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35349001754&partnerID=8YFLogxK

U2 - 10.1089/end.2006.0428

DO - 10.1089/end.2006.0428

M3 - Article

VL - 21

SP - 1117

EP - 1121

JO - Journal of Endourology

JF - Journal of Endourology

SN - 0892-7790

IS - 9

ER -