Use of clozapine to treat levodopa-induced psychosis in Parkinson's disease: Retrospective review

Lawrence P. Widman, William J. Burke, Ronald F. Pfeiffer, Delores McArthur-Campbell

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Levodopa-induced psychosis can complicate the treatment of Parkinson's disease (PD). In this retrospective, uncontrolled report, we describe our experience treating PD-related psychosis with clozapine, emphasizing those patients treated for longer than 1 year. Twenty-seven patients were treated, 14 for longer than 1 year. Most patients showed a rapid improvement from baseline within 1 month using the Clinical Global Impression and Global Psychosis Rating Scores. Five patients discontinued the drug due to side effects, but only two patients reported side effects after 6 months of treatment. Clozapine appears to be effective in treating PD related psychotic symptoms while not interfering with motor function.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalJournal of Geriatric Psychiatry and Neurology
Volume10
Issue number2
DOIs
StatePublished - Apr 1997

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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