TY - JOUR
T1 - Use of clozapine to treat levodopa-induced psychosis in Parkinson's disease
T2 - Retrospective review
AU - Widman, Lawrence P.
AU - Burke, William J.
AU - Pfeiffer, Ronald F.
AU - McArthur-Campbell, Delores
PY - 1997/4
Y1 - 1997/4
N2 - Levodopa-induced psychosis can complicate the treatment of Parkinson's disease (PD). In this retrospective, uncontrolled report, we describe our experience treating PD-related psychosis with clozapine, emphasizing those patients treated for longer than 1 year. Twenty-seven patients were treated, 14 for longer than 1 year. Most patients showed a rapid improvement from baseline within 1 month using the Clinical Global Impression and Global Psychosis Rating Scores. Five patients discontinued the drug due to side effects, but only two patients reported side effects after 6 months of treatment. Clozapine appears to be effective in treating PD related psychotic symptoms while not interfering with motor function.
AB - Levodopa-induced psychosis can complicate the treatment of Parkinson's disease (PD). In this retrospective, uncontrolled report, we describe our experience treating PD-related psychosis with clozapine, emphasizing those patients treated for longer than 1 year. Twenty-seven patients were treated, 14 for longer than 1 year. Most patients showed a rapid improvement from baseline within 1 month using the Clinical Global Impression and Global Psychosis Rating Scores. Five patients discontinued the drug due to side effects, but only two patients reported side effects after 6 months of treatment. Clozapine appears to be effective in treating PD related psychotic symptoms while not interfering with motor function.
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U2 - 10.1177/089198879701000205
DO - 10.1177/089198879701000205
M3 - Article
C2 - 9188021
AN - SCOPUS:0030879485
SN - 0891-9887
VL - 10
SP - 63
EP - 66
JO - Journal of Geriatric Psychiatry and Neurology
JF - Journal of Geriatric Psychiatry and Neurology
IS - 2
ER -