Use of chromosomally mapped and identified mouse brain proteins for behavioral genetic analysis of alcoholism

David Goldman, John Jr Crabbe

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

1. 1. A logical first place to look in order to identify loci determining behavioral differences between inbred and certain outbred strains of mice is among the proteins ex- pressed in brain. 2. 2. Fourteen mouse brain proteins have been demonstrated to be genetically variant, four of these have been chromosomally mapped and an additional twelve have been identified and can be simultaneously screened by two dimensional electrophoresls. 3. 3. Certain genetic differences in behavior relevant to alcohol consumption and the effects of alcohol occur between inbred, recombinant Inbred and selectively outbred strains. 4. 4. Two genetic correlations are reported, one between an isoelectric point variant of A7 (a 71 kd, pI 5.4 abundant protein) and resistance to signs of ethanol withdrawal and the other between A12 (a 28 kd, pI 5.6 protein) and ethanol intake. Though tentative, these findings illustrate the power of this approach for behavioral genetic analysis and may allow the biochemical genetic bases of these traits to be understood.

Original languageEnglish (US)
Pages (from-to)177-189
Number of pages13
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume10
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Behavioral Genetics
Alcoholism
Brain
Ethanol
Proteins
compound A 12
Isoelectric Point
Alcohol Drinking
Molecular Biology
Alcohols

Keywords

  • alcoholism
  • polymorphism
  • sedation
  • two-dimensional electrophoresis
  • withdrawal
  • WSP/WSR mice

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

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abstract = "1. 1. A logical first place to look in order to identify loci determining behavioral differences between inbred and certain outbred strains of mice is among the proteins ex- pressed in brain. 2. 2. Fourteen mouse brain proteins have been demonstrated to be genetically variant, four of these have been chromosomally mapped and an additional twelve have been identified and can be simultaneously screened by two dimensional electrophoresls. 3. 3. Certain genetic differences in behavior relevant to alcohol consumption and the effects of alcohol occur between inbred, recombinant Inbred and selectively outbred strains. 4. 4. Two genetic correlations are reported, one between an isoelectric point variant of A7 (a 71 kd, pI 5.4 abundant protein) and resistance to signs of ethanol withdrawal and the other between A12 (a 28 kd, pI 5.6 protein) and ethanol intake. Though tentative, these findings illustrate the power of this approach for behavioral genetic analysis and may allow the biochemical genetic bases of these traits to be understood.",
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AU - Crabbe, John Jr

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N2 - 1. 1. A logical first place to look in order to identify loci determining behavioral differences between inbred and certain outbred strains of mice is among the proteins ex- pressed in brain. 2. 2. Fourteen mouse brain proteins have been demonstrated to be genetically variant, four of these have been chromosomally mapped and an additional twelve have been identified and can be simultaneously screened by two dimensional electrophoresls. 3. 3. Certain genetic differences in behavior relevant to alcohol consumption and the effects of alcohol occur between inbred, recombinant Inbred and selectively outbred strains. 4. 4. Two genetic correlations are reported, one between an isoelectric point variant of A7 (a 71 kd, pI 5.4 abundant protein) and resistance to signs of ethanol withdrawal and the other between A12 (a 28 kd, pI 5.6 protein) and ethanol intake. Though tentative, these findings illustrate the power of this approach for behavioral genetic analysis and may allow the biochemical genetic bases of these traits to be understood.

AB - 1. 1. A logical first place to look in order to identify loci determining behavioral differences between inbred and certain outbred strains of mice is among the proteins ex- pressed in brain. 2. 2. Fourteen mouse brain proteins have been demonstrated to be genetically variant, four of these have been chromosomally mapped and an additional twelve have been identified and can be simultaneously screened by two dimensional electrophoresls. 3. 3. Certain genetic differences in behavior relevant to alcohol consumption and the effects of alcohol occur between inbred, recombinant Inbred and selectively outbred strains. 4. 4. Two genetic correlations are reported, one between an isoelectric point variant of A7 (a 71 kd, pI 5.4 abundant protein) and resistance to signs of ethanol withdrawal and the other between A12 (a 28 kd, pI 5.6 protein) and ethanol intake. Though tentative, these findings illustrate the power of this approach for behavioral genetic analysis and may allow the biochemical genetic bases of these traits to be understood.

KW - alcoholism

KW - polymorphism

KW - sedation

KW - two-dimensional electrophoresis

KW - withdrawal

KW - WSP/WSR mice

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