Use of autologous umbilical artery and vein for vascular reconstruction in the newborn

Angelo Vlessis, Hagop Hovaguimian, Eric Arntson, Albert Starr

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Autologous umbilical artery and vein were evaluated as vascular conduits in newborn lambs. Eight newborn lambs were delivered transabdominally under sterile conditions at term. The umbilical artery and vein were dissected from the cord and stored in culture media. On the same day, each lamb underwent bilateral superficial femoral artery transection and reconstruction. Nine arteries were reconstructed with autologous umbilical vein interposition grafts, five with umbilical artery interposition grafts, and two by primary native artery anastomosis. After the birth weight of the lambs quadrupled (37 to 45 days), they were killed and all grafts and anastomoses were examined grossly and histologically. At the conclusion of the study, both native artery anastomoses (2/2) were patent. Five umbilical vein (5/9) and two umbilical artery (2/5) autografts were also widely patent. Patent autografts retained an intact endothelium supported by a viable media. The nonpatent autografts had become atrophic remnants displaying histologic signs of early closure. Graft failures are attributed to the extreme vasoactive nature of the umbilical vessels. These preliminary results suggest that umbilical vessels may be useful as a vascular autograft if the vasoactive nature of these vessels can be overcome during the immediate perioperative period. (J THORAC CARDIOVASC SURG 1995;109:854-7).

Original languageEnglish (US)
Pages (from-to)854-857
Number of pages4
JournalThe Journal of thoracic and cardiovascular surgery
Volume109
Issue number5
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Umbilical Veins
Umbilical Arteries
Autografts
Blood Vessels
Transplants
Umbilicus
Arteries
Perioperative Period
Femoral Artery
Birth Weight
Endothelium
Culture Media

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Use of autologous umbilical artery and vein for vascular reconstruction in the newborn. / Vlessis, Angelo; Hovaguimian, Hagop; Arntson, Eric; Starr, Albert.

In: The Journal of thoracic and cardiovascular surgery, Vol. 109, No. 5, 1995, p. 854-857.

Research output: Contribution to journalArticle

Vlessis, Angelo ; Hovaguimian, Hagop ; Arntson, Eric ; Starr, Albert. / Use of autologous umbilical artery and vein for vascular reconstruction in the newborn. In: The Journal of thoracic and cardiovascular surgery. 1995 ; Vol. 109, No. 5. pp. 854-857.
@article{dab2684bab5843818248529a5402b286,
title = "Use of autologous umbilical artery and vein for vascular reconstruction in the newborn",
abstract = "Autologous umbilical artery and vein were evaluated as vascular conduits in newborn lambs. Eight newborn lambs were delivered transabdominally under sterile conditions at term. The umbilical artery and vein were dissected from the cord and stored in culture media. On the same day, each lamb underwent bilateral superficial femoral artery transection and reconstruction. Nine arteries were reconstructed with autologous umbilical vein interposition grafts, five with umbilical artery interposition grafts, and two by primary native artery anastomosis. After the birth weight of the lambs quadrupled (37 to 45 days), they were killed and all grafts and anastomoses were examined grossly and histologically. At the conclusion of the study, both native artery anastomoses (2/2) were patent. Five umbilical vein (5/9) and two umbilical artery (2/5) autografts were also widely patent. Patent autografts retained an intact endothelium supported by a viable media. The nonpatent autografts had become atrophic remnants displaying histologic signs of early closure. Graft failures are attributed to the extreme vasoactive nature of the umbilical vessels. These preliminary results suggest that umbilical vessels may be useful as a vascular autograft if the vasoactive nature of these vessels can be overcome during the immediate perioperative period. (J THORAC CARDIOVASC SURG 1995;109:854-7).",
author = "Angelo Vlessis and Hagop Hovaguimian and Eric Arntson and Albert Starr",
year = "1995",
doi = "10.1016/S0022-5223(95)70308-X",
language = "English (US)",
volume = "109",
pages = "854--857",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Use of autologous umbilical artery and vein for vascular reconstruction in the newborn

AU - Vlessis, Angelo

AU - Hovaguimian, Hagop

AU - Arntson, Eric

AU - Starr, Albert

PY - 1995

Y1 - 1995

N2 - Autologous umbilical artery and vein were evaluated as vascular conduits in newborn lambs. Eight newborn lambs were delivered transabdominally under sterile conditions at term. The umbilical artery and vein were dissected from the cord and stored in culture media. On the same day, each lamb underwent bilateral superficial femoral artery transection and reconstruction. Nine arteries were reconstructed with autologous umbilical vein interposition grafts, five with umbilical artery interposition grafts, and two by primary native artery anastomosis. After the birth weight of the lambs quadrupled (37 to 45 days), they were killed and all grafts and anastomoses were examined grossly and histologically. At the conclusion of the study, both native artery anastomoses (2/2) were patent. Five umbilical vein (5/9) and two umbilical artery (2/5) autografts were also widely patent. Patent autografts retained an intact endothelium supported by a viable media. The nonpatent autografts had become atrophic remnants displaying histologic signs of early closure. Graft failures are attributed to the extreme vasoactive nature of the umbilical vessels. These preliminary results suggest that umbilical vessels may be useful as a vascular autograft if the vasoactive nature of these vessels can be overcome during the immediate perioperative period. (J THORAC CARDIOVASC SURG 1995;109:854-7).

AB - Autologous umbilical artery and vein were evaluated as vascular conduits in newborn lambs. Eight newborn lambs were delivered transabdominally under sterile conditions at term. The umbilical artery and vein were dissected from the cord and stored in culture media. On the same day, each lamb underwent bilateral superficial femoral artery transection and reconstruction. Nine arteries were reconstructed with autologous umbilical vein interposition grafts, five with umbilical artery interposition grafts, and two by primary native artery anastomosis. After the birth weight of the lambs quadrupled (37 to 45 days), they were killed and all grafts and anastomoses were examined grossly and histologically. At the conclusion of the study, both native artery anastomoses (2/2) were patent. Five umbilical vein (5/9) and two umbilical artery (2/5) autografts were also widely patent. Patent autografts retained an intact endothelium supported by a viable media. The nonpatent autografts had become atrophic remnants displaying histologic signs of early closure. Graft failures are attributed to the extreme vasoactive nature of the umbilical vessels. These preliminary results suggest that umbilical vessels may be useful as a vascular autograft if the vasoactive nature of these vessels can be overcome during the immediate perioperative period. (J THORAC CARDIOVASC SURG 1995;109:854-7).

UR - http://www.scopus.com/inward/record.url?scp=0028903974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028903974&partnerID=8YFLogxK

U2 - 10.1016/S0022-5223(95)70308-X

DO - 10.1016/S0022-5223(95)70308-X

M3 - Article

C2 - 7739244

AN - SCOPUS:0028903974

VL - 109

SP - 854

EP - 857

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

SN - 0022-5223

IS - 5

ER -