Use of auditory brainstem responses for the early detection of ototoxicity from aminoglycosides or chemotherapeutic drugs

Curtin R. Mitchell, Roger M. Ellingson, James A. Henry, Stephen A. Fausti

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Effective objective HF (high-frequency) testing methodology provides for the early detection of ototoxic hearing loss because it typically progresses from high to low frequencies. Such early detection is considered necessary to prevent hearing loss from progressing into the frequency range important for understanding speech. Objective tests must be reliable, sensitive to hearing change, and time efficient. Auditory brainstem responses (ABRs) appear well suited to this task; however, current ABR techniques have limitations. Conventional clicks stimulate middle (1-4 kHz) rather than high frequencies (>8 kHz). Responses to HF tone bursts require considerable recording time. We hypothesized that using HF band-limited clicks (HF clicks) could overcome these limitations. Two different HF clicks, with bandwidths of 8-14 kHz were used to elicit ABRs. The current study compared responses among these stimuli. The results demonstrate the reliability of HF-click responses and of tone bursts presented in trains.

Original languageEnglish (US)
Pages (from-to)373-382
Number of pages10
JournalJournal of Rehabilitation Research and Development
Volume41
Issue number3 A
DOIs
StatePublished - 2004

Keywords

  • Auditory brainstem responses
  • Clicks
  • Early detection
  • Ototoxicity
  • Tone bursts

ASJC Scopus subject areas

  • Rehabilitation

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