Use of antidepressants and rates of hip bone loss in older women: The study of osteoporotic fractures

Susan J. Diem, Terri L. Blackwell, Katie L. Stone, Kristine Yaffe, Elizabeth Haney, Michael M. Bliziotes, Kristine E. Ensrud

Research output: Contribution to journalArticle

261 Citations (Scopus)

Abstract

Background: Serotonin transporters have recently been described in bone, raising the possibility that medications that block serotonin reuptake could affect bone metabolism. Methods: We assessed current use of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) and obtained serial bone mineral density (BMD) measurements in a cohort of 2722 older women (mean age, 78.5 years) participating in the Study of Osteoporotic Fractures, a prospective cohort study of community-dwelling women. Hip BMD was measured at the sixth examination and an average of 4.9 years later at the eighth examination. We categorized women as nonusers (used no SSRIs or TCAs at either examination; n=2406), SSRI users (used SSRIs but no TCAs at either examination; n=198), or TCA users (used TCAs but no SSRIs at either examination; n=118). Depressive symptoms were identified using a cutoff score of at least 6 on the Geriatric Depression Scale. Results: After adjustment for potential confounders, including the Geriatric Depression Scale score, mean total hip BMD decreased 0.47% per year in nonusers compared with 0.82% in SSRI users (P

Original languageEnglish (US)
Pages (from-to)1240-1245
Number of pages6
JournalArchives of Internal Medicine
Volume167
Issue number12
DOIs
StatePublished - Jun 25 2007

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Pelvic Bones
Osteoporotic Fractures
Serotonin Uptake Inhibitors
Tricyclic Antidepressive Agents
Antidepressive Agents
Bone Density
Depression
Geriatrics
Independent Living
Bone and Bones
Serotonin Plasma Membrane Transport Proteins
Serotonin
Cohort Studies
Prospective Studies

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Use of antidepressants and rates of hip bone loss in older women : The study of osteoporotic fractures. / Diem, Susan J.; Blackwell, Terri L.; Stone, Katie L.; Yaffe, Kristine; Haney, Elizabeth; Bliziotes, Michael M.; Ensrud, Kristine E.

In: Archives of Internal Medicine, Vol. 167, No. 12, 25.06.2007, p. 1240-1245.

Research output: Contribution to journalArticle

Diem, Susan J. ; Blackwell, Terri L. ; Stone, Katie L. ; Yaffe, Kristine ; Haney, Elizabeth ; Bliziotes, Michael M. ; Ensrud, Kristine E. / Use of antidepressants and rates of hip bone loss in older women : The study of osteoporotic fractures. In: Archives of Internal Medicine. 2007 ; Vol. 167, No. 12. pp. 1240-1245.
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