Use of a species-specific antibody for demonstrating mouse neurons transplanted to rat brains

R. D. Lund, F. L.F. Chang, M. H. Hankin, C. F. Lagenaur

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

A cell surface monoclonal antibody specific for mouse central nervous system neurons was used to identify mouse tissue transplanted to neonatal rat brains. Neuronal cell bodies and processes were stained in the transplants. Immature axons were stained growing out of the transplants into the host brain; and in mature brains unmyelinated axons and terminal plexuses were demonstrated. The technique allows a variety of studies to be performed on transplant-host interactions, especially in circumstances where the two are closely apposed.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalNeuroscience Letters
Volume61
Issue number1-2
DOIs
StatePublished - Oct 24 1985

Keywords

  • cerebellum
  • cortex
  • cross-species transplant
  • monoclonal antibody
  • retina

ASJC Scopus subject areas

  • Neuroscience(all)

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