Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques

Miles J. Novy, Lynn Duffy, Michael Axthelm, Drew W. Sadowsky, Steven S. Witkin, Michael G. Gravett, Gail H. Cassell, Kenneth B. Waites

    Research output: Contribution to journalArticle

    111 Citations (Scopus)

    Abstract

    The authors assess causal, cellular and inflammatory links between intraamniotic infection with Ureaplasma parvum or Mycoplasma hominis and preterm labor in a nonhuman primate model. Long-term catheterized rhesus monkeys received intraamniotic inoculations of clinical isolates of Ureaplasma parvum serovar 1, M hominis, media control or physiological saline. Genital mycoplasmas were quantified in amniotic fluid (AF) and documented in fetal tissues by culture and PCR. In association with elevated AF colony counts for U parvum or M hominis, there was a sequential upregulation of AF leukocytes, proinflammatory cytokines, prostaglandin E2 and F2a, metalloproteinase-9 and uterine activity ( P

    Original languageEnglish (US)
    Pages (from-to)56-70
    Number of pages15
    JournalReproductive Sciences
    Volume16
    Issue number1
    DOIs
    StatePublished - Jan 2009

    Fingerprint

    Mycoplasma hominis
    Ureaplasma
    Chorioamnionitis
    Amniotic Fluid
    Macaca mulatta
    Pneumonia
    Premature Obstetric Labor
    Mycoplasma
    Metalloproteases
    Dinoprostone
    Primates
    Fetus
    Leukocytes
    Up-Regulation
    Cytokines
    Polymerase Chain Reaction
    Infection

    Keywords

    • Chorioamnionitis
    • Fetal lung
    • Intrauterine infection/inflammation
    • Mycoplasma
    • Preterm labor
    • Rhesus monkey
    • Ureaplasma

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

    Cite this

    Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques. / Novy, Miles J.; Duffy, Lynn; Axthelm, Michael; Sadowsky, Drew W.; Witkin, Steven S.; Gravett, Michael G.; Cassell, Gail H.; Waites, Kenneth B.

    In: Reproductive Sciences, Vol. 16, No. 1, 01.2009, p. 56-70.

    Research output: Contribution to journalArticle

    Novy, Miles J. ; Duffy, Lynn ; Axthelm, Michael ; Sadowsky, Drew W. ; Witkin, Steven S. ; Gravett, Michael G. ; Cassell, Gail H. ; Waites, Kenneth B. / Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques. In: Reproductive Sciences. 2009 ; Vol. 16, No. 1. pp. 56-70.
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    AU - Axthelm, Michael

    AU - Sadowsky, Drew W.

    AU - Witkin, Steven S.

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