Ureaplasma Infection and Neonatal Lung Disease

Robert L. Schelonka, Ken B. Waites

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

Infection with the ureaplasmas may occur in utero or perinatally in prematurely born infants. For some infants, infection with these organisms triggers a vigorous pro-inflammatory response in the lungs and increases the risk of developing bronchopulmonary dysplasia (BPD). At present, there is insufficient evidence from clinical trials to determine whether antibiotic treatment of Ureaplasma has any influence on the development of BPD and its comorbidities. Future investigation in the context of well-designed, adequately powered controlled clinical trials should focus on determining whether treatment of ureaplasmal infection lessens lung inflammation, decreases rates of BPD, and improves long-term, neurodevelopmental outcome.

Original languageEnglish (US)
Pages (from-to)2-9
Number of pages8
JournalSeminars in Perinatology
Volume31
Issue number1
DOIs
StatePublished - Feb 1 2007

Keywords

  • Ureaplasma
  • bronchopulmonary dysplasia
  • newborn infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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