Upregulation of MUC4 in cervical squamous cell carcinoma

Pathologic significance

Elizabeth Munro, Maneesh Jain, Esther Oliva, Neel Kamal, Subodh M. Lele, Maureen P. Lynch, Lankai Guo, Kai Fu, Poonam Sharma, Steve Remmenga, Whitfield B. Growdon, John S. Davis, Bo R. Rueda, Surinder K. Batra

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

MUC4 is a transmembrane glycoprotein more highly expressed in cervical dysplasia than benign cervical epithelium. We sought to determine whether MUC4 expression differs between benign and malignant cervical tissue. Fifty-eight patients with benign, dysplastic, or malignant cervical pathology were identified retrospectively, and representative sections were stained with a mouse monoclonal anti-MUC4 antibody. Semiquantitative analysis was performed on benign, dysplastic, and malignant regions by scoring staining intensity (0: negative, 1: weak, 2: moderate, and 3: strong) and distribution (focal

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalInternational Journal of Gynecological Pathology
Volume28
Issue number2
DOIs
StatePublished - Mar 2009
Externally publishedYes

Fingerprint

Uterine Cervical Dysplasia
Anti-Idiotypic Antibodies
Squamous Cell Carcinoma
Glycoproteins
Up-Regulation
Epithelium
Monoclonal Antibodies
Pathology
Staining and Labeling

Keywords

  • Adenocarcinoma
  • Cervical cancer
  • MUC4
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

Cite this

Upregulation of MUC4 in cervical squamous cell carcinoma : Pathologic significance. / Munro, Elizabeth; Jain, Maneesh; Oliva, Esther; Kamal, Neel; Lele, Subodh M.; Lynch, Maureen P.; Guo, Lankai; Fu, Kai; Sharma, Poonam; Remmenga, Steve; Growdon, Whitfield B.; Davis, John S.; Rueda, Bo R.; Batra, Surinder K.

In: International Journal of Gynecological Pathology, Vol. 28, No. 2, 03.2009, p. 127-133.

Research output: Contribution to journalArticle

Munro, E, Jain, M, Oliva, E, Kamal, N, Lele, SM, Lynch, MP, Guo, L, Fu, K, Sharma, P, Remmenga, S, Growdon, WB, Davis, JS, Rueda, BR & Batra, SK 2009, 'Upregulation of MUC4 in cervical squamous cell carcinoma: Pathologic significance', International Journal of Gynecological Pathology, vol. 28, no. 2, pp. 127-133. https://doi.org/10.1097/PGP.0b013e318184f3e0
Munro, Elizabeth ; Jain, Maneesh ; Oliva, Esther ; Kamal, Neel ; Lele, Subodh M. ; Lynch, Maureen P. ; Guo, Lankai ; Fu, Kai ; Sharma, Poonam ; Remmenga, Steve ; Growdon, Whitfield B. ; Davis, John S. ; Rueda, Bo R. ; Batra, Surinder K. / Upregulation of MUC4 in cervical squamous cell carcinoma : Pathologic significance. In: International Journal of Gynecological Pathology. 2009 ; Vol. 28, No. 2. pp. 127-133.
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