Upper and lower extremities in Duchenne muscular dystrophy evaluated with quantitative MRI and proton MR spectroscopy in a multicenter cohort

Sean C. Forbes, Harneet Arora, Rebecca J. Willcocks, William T. Triplett, William D. Rooney, Alison M. Barnard, Umar Alabasi, Dah Jyuu Wang, Donovan J. Lott, Claudia R. Senesac, Ann T. Harrington, Erika L. Finanger, Gihan I. Tennekoon, John Brandsema, Michael J. Daniels, H. Lee Sweeney, Glenn A. Walter, Krista Vandenborne

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Upper extremity MRI and proton MR spectroscopy are increasingly considered to be outcome measures in Duchenne muscular dystrophy (DMD) clinical trials. Purpose: To demonstrate the feasibility of acquiring upper extremity MRI and proton (1H) MR spectroscopy measures of T2 and fat fraction in a large, multicenter cohort (ImagingDMD) of ambulatory and nonambulatory individuals with DMD; compare upper and lower extremity muscles by using MRI and 1H MR spectroscopy; and correlate upper extremity MRI and 1H MR spectroscopy measures to function. Materials and Methods: In this prospective cross-sectional study, MRI and 1H MR spectroscopy and functional assessment data were acquired from participants with DMD and unaffected control participants at three centers (from January 28, 2016, to April 24, 2018). T2 maps of the shoulder, upper arm, forearm, thigh, and calf were generated from a spin-echo sequence (repetition time msec/echo time msec, 3000/20-320). Fat fraction maps were generated from chemical shift-encoded imaging (eight echo times). Fat fraction and 1HO T2 in the deltoid and biceps brachii were measured from single-voxel 1H MR spectroscopy (9000/11-243). Groups were compared by using Mann-Whitney test, and relationships between MRI and 1H MR spectroscopy and arm function were assessed by using Spearman correlation. Results: This study evaluated 119 male participants with DMD (mean age, 12 years ± 3 [standard deviation]) and 38 unaffected male control participants (mean age, 12 years ± 3). Deltoid and biceps brachii muscles were different in participants with DMD versus control participants in all age groups by using quantitative T2 MRI (P <.001) and 1H MR spectroscopy fat fraction (P <.05). The deltoid, biceps brachii, and triceps brachii were afected to the same extent (P >.05) as the soleus and medial gastrocnemius. Negative correlations were observed between arm function and MRI (T2: range among muscles, r = 20.53 to 20.73 [P <.01]; fat fraction, r = 20.49 to 20.70 [P <.01]) and 1H MR spectroscopy fat fraction (r = 20.64 to 20.71; P <.01). Conclusion: This multicenter study demonstrated early and progressive involvement of upper extremity muscles in Duchenne muscular dystrophy (DMD) and showed the feasibility of MRI and 1H MR spectroscopy to track disease progression over a wide range of ages in participants with DMD.

Original languageEnglish (US)
Pages (from-to)616-625
Number of pages10
JournalRADIOLOGY
Volume295
Issue number3
DOIs
StatePublished - Jun 2020

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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