Updates in rare and not-so-rare complications of acromegaly: Focus on respiratory function and quality of life in acromegaly

Maria Fleseriu, Fabienne Langlois, Gabriela M. Suarez

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Acromegaly is a complex disease with excessive growth hormone and insulin-like growth factor 1 (IGF-1) causing multisystem effects, particularly cardiovascular, respiratory, and metabolic. Psychological concerns and poor quality of life (QoL) are also major disease consequences. This review is intended for clinicians and focuses on the latest developments related to respiratory and QoL effects of long-term growth hormone excess. Along with biochemical disease control, patient treatment satisfaction and outcomes have become major treatment objectives; current knowledge and tools to evaluate and manage this aspect of the disease are described. Sleep apnea syndrome and other derangements of lung function and apparatus, from pathophysiology to treatment, and evaluation tools and determinants of QoL in patients with acromegaly are discussed.

Original languageEnglish (US)
Article number791
JournalF1000Research
Volume9
DOIs
StatePublished - 2020

Keywords

  • Acromegaly
  • Growth hormone excess
  • Patients reported outcome
  • Quality of life
  • Respiratory complication
  • Sleep apnea

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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