Updates in Pediatric Glioma Pathology

Melanie H. Hakar; Matthew D. Wood

doi:10.1016/j.path.2020.08.006

Updates in Pediatric Glioma Pathology

Melanie H. Hakar, Matthew D. Wood

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Gliomas are a diverse group of primary central nervous system tumors with astrocytic, oligodendroglial, and/or ependymal features and are an important cause of morbidity/mortality in pediatric patients. Glioma classification relies on integrating tumor histology with key molecular alterations. This approach can help establish a diagnosis, guide treatment, and determine prognosis. New categories of pediatric glioma have been recognized in recent years, due to increasing application of molecular profiling in brain tumors. The aim of this review is to alert pediatric pathologists to emerging diagnostic concepts in pediatric glioma neuropathology, emphasizing the incorporation of molecular features into diagnostic practice.

Original language	English (US)
Pages (from-to)	801-816
Number of pages	16
Journal	Surgical Pathology Clinics
Volume	13
Issue number	4
DOIs	https://doi.org/10.1016/j.path.2020.08.006
State	Published - Dec 2020

Keywords

Astrocytoma
Glioblastoma
Glioma
Molecular profiling
Pediatric

ASJC Scopus subject areas

Surgery
Pathology and Forensic Medicine

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10.1016/j.path.2020.08.006

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title = "Updates in Pediatric Glioma Pathology",

abstract = "Gliomas are a diverse group of primary central nervous system tumors with astrocytic, oligodendroglial, and/or ependymal features and are an important cause of morbidity/mortality in pediatric patients. Glioma classification relies on integrating tumor histology with key molecular alterations. This approach can help establish a diagnosis, guide treatment, and determine prognosis. New categories of pediatric glioma have been recognized in recent years, due to increasing application of molecular profiling in brain tumors. The aim of this review is to alert pediatric pathologists to emerging diagnostic concepts in pediatric glioma neuropathology, emphasizing the incorporation of molecular features into diagnostic practice.",

keywords = "Astrocytoma, Glioblastoma, Glioma, Molecular profiling, Pediatric",

author = "Hakar, {Melanie H.} and Wood, {Matthew D.}",

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year = "2020",

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AU - Hakar, Melanie H.

AU - Wood, Matthew D.

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AB - Gliomas are a diverse group of primary central nervous system tumors with astrocytic, oligodendroglial, and/or ependymal features and are an important cause of morbidity/mortality in pediatric patients. Glioma classification relies on integrating tumor histology with key molecular alterations. This approach can help establish a diagnosis, guide treatment, and determine prognosis. New categories of pediatric glioma have been recognized in recent years, due to increasing application of molecular profiling in brain tumors. The aim of this review is to alert pediatric pathologists to emerging diagnostic concepts in pediatric glioma neuropathology, emphasizing the incorporation of molecular features into diagnostic practice.

KW - Astrocytoma

KW - Glioblastoma

KW - Glioma

KW - Molecular profiling

KW - Pediatric

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M3 - Review article

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JF - Surgical Pathology Clinics

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Updates in Pediatric Glioma Pathology

Abstract

Keywords

ASJC Scopus subject areas

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