Original language | English (US) |
---|---|
Article number | 113327 |
Journal | Food and Chemical Toxicology |
Volume | 167 |
DOIs | |
State | Published - Sep 2022 |
ASJC Scopus subject areas
- Food Science
- Toxicology
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In: Food and Chemical Toxicology, Vol. 167, 113327, 09.2022.
Research output: Contribution to journal › Short survey › peer-review
}
TY - JOUR
T1 - Update to RIFM fragrance ingredient safety assessment, linalyl phenylacetate, CAS Registry Number 7143-69-3
AU - Api, A. M.
AU - Belsito, D.
AU - Botelho, D.
AU - Bruze, M.
AU - Burton, G. A.
AU - Cancellieri, M. A.
AU - Chon, H.
AU - Dagli, M. L.
AU - Date, M.
AU - Dekant, W.
AU - Deodhar, C.
AU - Fryer, A. D.
AU - Jones, L.
AU - Joshi, K.
AU - Kumar, M.
AU - Lapczynski, A.
AU - Lavelle, M.
AU - Lee, I.
AU - Liebler, D. C.
AU - Moustakas, H.
AU - Na, M.
AU - Penning, T. M.
AU - Ritacco, G.
AU - Romine, J.
AU - Sadekar, N.
AU - Schultz, T. W.
AU - Selechnik, D.
AU - Siddiqi, F.
AU - Sipes, I. G.
AU - Sullivan, G.
AU - Thakkar, Y.
AU - Tokura, Y.
N1 - Funding Information: Limited skin sensitization data are available for linalyl phenylacetate (Table 1). The chemical structure of this material indicates that it would not be expected to react with skin proteins directly (Roberts et al., 2007; OECD Toolbox v4.2). In guinea pig test methods, no results indicative of sensitization were observed (Klecak, 1985; RIFM, 2000b). Additionally, no reactions indicative of skin sensitization were observed in a human maximization test (RIFM, 1974). Due to the limited data, the reported exposure was benchmarked utilizing the non-reactive DST of 900 μg/cm2 (Safford, 2008; Safford et al., 2011, 2015b; Roberts et al., 2015). The current exposure from the 95th percentile concentration is below the DST for non-reactive materials when evaluated in all QRA categories. Table 2 provides the supported concentrations for linalyl phenylacetate that present no appreciable risk for skin sensitization based on the non-reactive DST. These levels represent supported concentrations based on the DST approach. However, additional studies may show it could be used at higher levels.
PY - 2022/9
Y1 - 2022/9
UR - http://www.scopus.com/inward/record.url?scp=85136538756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85136538756&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2022.113327
DO - 10.1016/j.fct.2022.113327
M3 - Short survey
C2 - 35940328
AN - SCOPUS:85136538756
SN - 0278-6915
VL - 167
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
M1 - 113327
ER -