Update to RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5

A. M. Api; D. Belsito; D. Botelho; M. Bruze; G. A. Burton; M. A. Cancellieri; H. Chon; M. L. Dagli; M. Date; W. Dekant; C. Deodhar; A. D. Fryer; L. Jones; K. Joshi; M. Kumar; A. Lapczynski; M. Lavelle; I. Lee; D. C. Liebler; H. Moustakas; M. Na; T. M. Penning; G. Ritacco; J. Romine; N. Sadekar; T. W. Schultz; D. Selechnik; F. Siddiqi; I. G. Sipes; G. Sullivan; Y. Thakkar; Y. Tokura

doi:10.1016/j.fct.2022.113413

Update to RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5

A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, M. A. Cancellieri, H. Chon, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. Lee, D. C. Liebler, H. MoustakasM. Na, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, T. W. Schultz, D. Selechnik, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura

Pulmonary & Critical Care Medicine

Research output: Contribution to journal › Short survey › peer-review

Original language	English (US)
Article number	113413
Journal	Food and Chemical Toxicology
Volume	169
DOIs	https://doi.org/10.1016/j.fct.2022.113413
State	Published - Dec 2022

ASJC Scopus subject areas

Food Science
Toxicology

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10.1016/j.fct.2022.113413

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Api, A. M., Belsito, D., Botelho, D., Bruze, M., Burton, G. A., Cancellieri, M. A., Chon, H., Dagli, M. L., Date, M., Dekant, W., Deodhar, C., Fryer, A. D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D. C., ... Tokura, Y. (2022). Update to RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5. Food and Chemical Toxicology, 169, [113413]. https://doi.org/10.1016/j.fct.2022.113413

Api, AM, Belsito, D, Botelho, D, Bruze, M, Burton, GA, Cancellieri, MA, Chon, H, Dagli, ML, Date, M, Dekant, W, Deodhar, C, Fryer, AD, Jones, L, Joshi, K, Kumar, M, Lapczynski, A, Lavelle, M, Lee, I, Liebler, DC, Moustakas, H, Na, M, Penning, TM, Ritacco, G, Romine, J, Sadekar, N, Schultz, TW, Selechnik, D, Siddiqi, F, Sipes, IG, Sullivan, G, Thakkar, Y & Tokura, Y 2022, 'Update to RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5', Food and Chemical Toxicology, vol. 169, 113413. https://doi.org/10.1016/j.fct.2022.113413

@article{4a7e8ac4eeb149168249b6563d0ffa7c,

title = "Update to RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5",

author = "Api, {A. M.} and D. Belsito and D. Botelho and M. Bruze and Burton, {G. A.} and Cancellieri, {M. A.} and H. Chon and Dagli, {M. L.} and M. Date and W. Dekant and C. Deodhar and Fryer, {A. D.} and L. Jones and K. Joshi and M. Kumar and A. Lapczynski and M. Lavelle and I. Lee and Liebler, {D. C.} and H. Moustakas and M. Na and Penning, {T. M.} and G. Ritacco and J. Romine and N. Sadekar and Schultz, {T. W.} and D. Selechnik and F. Siddiqi and Sipes, {I. G.} and G. Sullivan and Y. Thakkar and Y. Tokura",

note = "Funding Information: The current exposure from the 95th percentile concentrations is below the supported concentrations when evaluated in all QRA categories (RIFM, 2019). Table 2 provides the supported concentrations for 4-(3,4-methylenedioxyphenyl)-2-butanone that present no appreciable risk for skin sensitization. These levels represent the supported concentrations based on a tested exposure of 2362 μg/cm2 in the CNIH (RIFM, 2015b). However, additional studies may show it could be used at higher levels.",

year = "2022",

month = dec,

doi = "10.1016/j.fct.2022.113413",

language = "English (US)",

volume = "169",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Update to RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5

AU - Api, A. M.

AU - Belsito, D.

AU - Botelho, D.

AU - Bruze, M.

AU - Burton, G. A.

AU - Cancellieri, M. A.

AU - Chon, H.

AU - Dagli, M. L.

AU - Date, M.

AU - Dekant, W.

AU - Deodhar, C.

AU - Fryer, A. D.

AU - Jones, L.

AU - Joshi, K.

AU - Kumar, M.

AU - Lapczynski, A.

AU - Lavelle, M.

AU - Lee, I.

AU - Liebler, D. C.

AU - Moustakas, H.

AU - Na, M.

AU - Penning, T. M.

AU - Ritacco, G.

AU - Romine, J.

AU - Sadekar, N.

AU - Schultz, T. W.

AU - Selechnik, D.

AU - Siddiqi, F.

AU - Sipes, I. G.

AU - Sullivan, G.

AU - Thakkar, Y.

AU - Tokura, Y.

N1 - Funding Information: The current exposure from the 95th percentile concentrations is below the supported concentrations when evaluated in all QRA categories (RIFM, 2019). Table 2 provides the supported concentrations for 4-(3,4-methylenedioxyphenyl)-2-butanone that present no appreciable risk for skin sensitization. These levels represent the supported concentrations based on a tested exposure of 2362 μg/cm2 in the CNIH (RIFM, 2015b). However, additional studies may show it could be used at higher levels.

PY - 2022/12

Y1 - 2022/12

UR - http://www.scopus.com/inward/record.url?scp=85138759677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85138759677&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2022.113413

DO - 10.1016/j.fct.2022.113413

M3 - Short survey

C2 - 36089192

AN - SCOPUS:85138759677

SN - 0278-6915

VL - 169

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

M1 - 113413

ER -

Update to RIFM fragrance ingredient safety assessment, 4-(3,4-methylenedioxyphenyl)-2-butanone, CAS Registry Number 55418-52-5

ASJC Scopus subject areas

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