Update on the rheumatologic manifestations of malignancy

Lianne Marks, Clifton D. Fuller, Parag Sanghvi, Melva Pinn, Charles Thomas

Research output: Contribution to journalArticle

Abstract

Malignancy can be accompanied by rheumatologic clinical findings, and these can occur prior to, concurrently with, or after a diagnosis of cancer. Certain clinical information helps to differentiate paraneoplastic symptoms from those more characteristic of classic rheumatologic disorders such as rheumtoid arthritis or systemic lupus erythematosus. Clinicians need to have a higher level of suspicion for malignancy in a patient with rheumatologic manifestationns in certain populations. This may be the case in patients with a personal or family history of malignancy, atypical presentations of rheumatologic disorders, and certain clinical situations (such as hypertrophic osteoarthropathy, carcinoma polyarthritis, dermatomyositis, and unilateral sacroiliitis). The current standard of care for patients with a rheumatologic disorder with a known paraneoplastic association (i.e., dermatomyositis) is age-appropriate cancer screening. This review is designed to guide the physician to musculoskeletal signs and symptoms that may be paraneoplastic in origin. Additionally, when the clinician understands current information regarding malignant associations, it will help them decide when it may be appropriate to pursue further investigative work-up or evaluate for recurrence of a known primary tumor.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalCurrent Cancer Therapy Reviews
Volume3
Issue number3
DOIs
StatePublished - Aug 2007

Fingerprint

Dermatomyositis
Neoplasms
Arthritis
Sacroiliitis
Standard of Care
Early Detection of Cancer
Systemic Lupus Erythematosus
Signs and Symptoms
Carcinoma
Physicians
Recurrence
Population

Keywords

  • Dermatomyositis
  • Hypertrophic osteoarthropathy
  • Lymphoma
  • Neoplastic process
  • Vasculitis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Molecular Medicine

Cite this

Update on the rheumatologic manifestations of malignancy. / Marks, Lianne; Fuller, Clifton D.; Sanghvi, Parag; Pinn, Melva; Thomas, Charles.

In: Current Cancer Therapy Reviews, Vol. 3, No. 3, 08.2007, p. 215-222.

Research output: Contribution to journalArticle

Marks, Lianne ; Fuller, Clifton D. ; Sanghvi, Parag ; Pinn, Melva ; Thomas, Charles. / Update on the rheumatologic manifestations of malignancy. In: Current Cancer Therapy Reviews. 2007 ; Vol. 3, No. 3. pp. 215-222.
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