Update on the epidemiology of pulmonary nontuberculous mycobacterial infections

Brian A. Kendall, Kevin Winthrop

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

For decades, the incidence of pulmonary nontuberculous mycobacteria (NTM) has been reported to be increasing, yet formal epidemiological evaluation of this notion has been lacking until recently. Defining the epidemiology of NTM has been more challenging than with Mycobacterium tuberculosis (MTB). Unlike MTB, NTM are soil and water organisms, and infection is thought to be acquired from the environment rather than transmitted from person-to-person, with very rare exceptions. Due to their nearly ubiquitous presence in municipal water supplies, exposure to NTM is common. Further, NTM can colonize the respiratory tract without causing disease. NTM disease is not reportable to public health authorities; therefore, epidemiological and surveillance data are not readily available. Nonetheless, the prevalence of pulmonary NTM disease has increased dramatically in the United States and globally over the past 3 decades. Mycobacterium avium complex (MAC) accounts for the majority of NTM infections worldwide, but there is significant regional variability of various species. Additionally, novel species have been implicated in several countries in NTM pulmonary disease.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalSeminars in Respiratory and Critical Care Medicine
Volume34
Issue number1
DOIs
StatePublished - 2013

Fingerprint

Nontuberculous Mycobacteria
Epidemiology
Lung
Infection
Mycobacterium tuberculosis
Nontuberculous Mycobacterium Infections
Mycobacterium avium Complex
Water Supply
Respiratory System
Lung Diseases
Soil
Public Health
Water
Incidence

Keywords

  • epidemiology
  • Mycobacterium avium
  • Mycobacterium tuberculosis
  • nontuberculous mycobacteria

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Update on the epidemiology of pulmonary nontuberculous mycobacterial infections. / Kendall, Brian A.; Winthrop, Kevin.

In: Seminars in Respiratory and Critical Care Medicine, Vol. 34, No. 1, 2013, p. 87-94.

Research output: Contribution to journalArticle

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