Update on the epidemiology and management of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, in patients with cystic fibrosis

Anne Stone, Lisa Saiman

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

PURPOSE OF REVIEW: Staphylococcus aureus is one of the first and most common pathogens to be isolated from the respiratory tract of patients with cystic fibrosis. The prevalence of respiratory tract colonization/infection with both methicillin-susceptible and methicillin-resistant S. aureus has increased over the past decade. The clinical significance of colonization/infection with these pathogens is variable, leading to numerous therapeutic strategies: primary prophylaxis, eradication, treatment of cystic fiboris pulmonary exacerbations, and treatment of methicillin-resistant S. aureus. RECENT FINDINGS: Studies have demonstrated increased prevalence of S. aureus in clinical laboratories that use selective media. Additionally, small colony variant S. aureus has been associated with persistent infection, co-infection with Pseudomonas aeruginosa, and frequent courses of antibiotics, but this phenotype may be difficult to identify in clinical laboratories. Increased prevalence of methicillin-resistant S. aureus has led to use of oral and inhaled antibiotics in attempts to eradicate this pathogen; these studies have yielded variable results. SUMMARY: The epidemiology of S. aureus in cystic fibrosis has changed. Studies are needed to assess the clinical significance of the increased prevalence of both methicillin-susceptible and methicillin-resistant S. aureus, and whether primary prophylaxis or new treatment/eradication protocols are effective.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalCurrent opinion in pulmonary medicine
Volume13
Issue number6
DOIs
StatePublished - Nov 1 2007

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Keywords

  • Epidemiology
  • Eradication
  • Methicillin-resistant
  • Small colony variant
  • Staphylococcus aureus
  • Virulence

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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