Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity, and more. Did they fail to predict the efficacy of T-cell vaccines in humans? This article summarizes progress and status of models to inform and complement clinical work.
|Original language||English (US)|
|Number of pages||6|
|Journal||European Journal of Immunology|
|State||Published - Aug 2009|
- Nonhuman primate
ASJC Scopus subject areas
- Immunology and Allergy