Update on animal models for HIV research

    Research output: Contribution to journalReview article

    21 Scopus citations

    Abstract

    Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity, and more. Did they fail to predict the efficacy of T-cell vaccines in humans? This article summarizes progress and status of models to inform and complement clinical work.

    Original languageEnglish (US)
    Pages (from-to)1994-1999
    Number of pages6
    JournalEuropean Journal of Immunology
    Volume39
    Issue number8
    DOIs
    StatePublished - Aug 1 2009

    Keywords

    • AIDS
    • HIV-1
    • Nonhuman primate
    • SHIV
    • SIV

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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